Adapting IMRT delivery fraction-by-fraction to cater for variable intrafraction motion

Physics in Medicine and Biology
S Webb

Abstract

This paper presents a technique for coping with variable intrafraction organ motion when delivering intensity-modulated radiation therapy (IMRT). The strategy is an adaptive delivery in which the fluence delivered up to a particular fraction is subtracted from the required total-course planned fluence to create an adapted residual fluence for the next fraction. This requires that the fluence already delivered can be computed, knowing the intrafraction motion during each fraction. If the adaptation is unconstrained, as would be required for perfect delivery of the planned fluence, then the individual fractional fluences would become unphysical, with both negative components and spikes. Hence it is argued that constraints must be applied; first, positivity constraints and second, constraints to limit fluence spikes. Additionally, it is shown to be helpful to constrain other quantities which are explained. The power of the strategy is that it adapts to the (potentially variable) moving geometry during each fraction. It is not a perfect delivery but it is always better than making no adaptation. The fractionated nature of radiation therapy is thus exploited to advantage. The fluence adaptation method does not require re-planning at...Continue Reading

References

Aug 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J SteinW Schlegel
Feb 24, 2001·Physics in Medicine and Biology·P J KeallR Mohan
Mar 12, 2004·Physics in Medicine and Biology·Gregory C SharpHiroki Shirato
Sep 21, 2004·Medical Physics·S S VedamR Mohan
Feb 22, 2005·Medical Physics·Lech Papiez, Dharanipathy Rangaraj
Jun 23, 2006·Physics in Medicine and Biology·S Webb
Aug 11, 2006·Medical Physics·Dan RuanJan-Jakob Sonke
Oct 3, 2006·Seminars in Radiation Oncology·Steve B Jiang
Oct 7, 2006·Medical Physics·Pai-Chun Melinda ChiTinsu Pan
Oct 7, 2006·Medical Physics·Jamie R McClellandDavid J Hawkes
Mar 1, 2007·Physics in Medicine and Biology·M von SiebenthalPh Cattin
May 16, 2007·Medical Physics·Mihaela RosuRandall K Ten Haken
Aug 1, 2007·Physics in Medicine and Biology·Adam de la ZerdaLei Xing
Aug 3, 2007·Physics in Medicine and Biology·Huanmei WuSteve B Jiang

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Citations

Jan 11, 2012·Radiation Protection Dosimetry·Luciano GonzalezCarlos Ubeda
Feb 16, 2012·Radiation Protection Dosimetry·Angélica Pérez-AndújarJonathan Farr
May 6, 2015·PloS One·Velibor V Mišić, Timothy C Y Chan
May 23, 2008·Physics in Medicine and Biology·Philip M Evans
Feb 11, 2009·Physics in Medicine and Biology·C K Ross, N V Klassen
Jan 16, 2010·Microbiology·Paul W WhitbyTerrence L Stull
Dec 15, 2010·Physics in Medicine and Biology·J R McClellandD J Hawkes
Feb 15, 2012·Physics in Medicine and Biology·Jagdish RamakrishnanJohn N Tsitsiklis
Nov 21, 2012·Physics in Medicine and Biology·Stine S Korreman

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