Adaption by Rewiring Epigenetic Landscapes

Cell Stem Cell
Yifei Liu, Andrew Xiao

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

Citations

Jan 20, 2016·Journal of Cellular and Molecular Medicine·Ting XuHongqi Zhang
Mar 30, 2016·Seminars in Cell & Developmental Biology·Dragos Cretoiu, Sanda Maria Cretoiu

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