Adaptive acid tolerance response of Streptococcus sobrinus

Journal of Bacteriology
Marcelle M NascimentoRobert A Burne

Abstract

Streptococcus mutans and Streptococcus sobrinus are the bacteria most commonly associated with human dental caries. A major virulence attribute of these and other cariogenic bacteria is acid tolerance. The acid tolerance mechanisms of S. mutans have begun to be investigated in detail, including the adaptive acid tolerance response (ATR), but this is not the case for S. sobrinus. An analysis of the ATR of two S. sobrinus strains was conducted with cells grown to steady state in continuous chemostat cultures. Compared with cells grown at neutral pH, S. sobrinus cells grown at pH 5.0 showed an increased resistance to acid killing and were able to drive down the pH through glycolysis to lower values. Unlike what is found for S. mutans, the enhanced acid tolerance and glycolytic capacities of acid-adapted S. sobrinus were not due to increased F-ATPase activities. Interestingly though, S. sobrinus cells grown at pH 5.0 had twofold more glucose phosphoenolpyruvate:sugar phosphotransferase system (PTS) activity than cells grown at pH 7.0. In contrast, glucose PTS activity was actually higher in S. mutans grown at pH 7.0 than in cells grown at pH 5.0. Silver staining of two-dimensional gels of whole-cell lysates of S. sobrinus 6715 reve...Continue Reading

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Citations

Jul 24, 2010·Photomedicine and Laser Surgery·Mayte BoleanPietro Ciancaglini
Nov 14, 2006·Applied and Environmental Microbiology·Konstantinos PapadimitriouEffie Tsakalidou
Mar 3, 2009·Applied and Environmental Microbiology·Sug-Joon AhnRobert A Burne
Jan 29, 2008·Journal of Bacteriology·Jacqueline AbranchesRobert A Burne
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Jul 6, 2021·Veterinary World·Afiqah Zafirah Abdul RahmanAbubakar Musa Mayaki

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