PMID: 8957547Jan 1, 1996Paper

Adaptive and genetic alterations of the renin angiotensin system in cardiac hypertrophy and failure

Basic Research in Cardiology
S R Holmer, H Schunkert

Abstract

The risk to suffer from cardiovascular events may be modulated, in part, by neurohormonal systems. Neurohormones such as angiotensin II or aldosterone may be activated secondary to congestive heart failure or in the course of an acute myocardial infarction. These systems, if activated, will subject the failing heart to increased hemodynamic load and, thus, further compromise cardiac function. In addition, structural changes of the heart and vessels occurring with pressure or volume overload may be amplified by the growth promoting effects of these agents. Taken together, the interaction of underlying cardiovascular disease and activated neurohormones may often determine clinical symptoms and prognosis. More recently, growing evidence suggests that the basal, genetically determined, activity of the renin angiotensin aldosterone system may relate to the development of cardiovascular disease as well. In particular, variants of the angiotensinogen and angiotensin converting enzyme genes have been associated with essential hypertension, myocardial infarction, or left ventricular hypertrophy. In this regard, the data suggest that the renin angiotensin aldosterone system may be one of the primary causes, rather than only a secondary c...Continue Reading

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Citations

Nov 17, 2001·The Journal of Physiology·J P BénitahG Vassort
Mar 23, 2006·Journal of the American Geriatrics Society·Barbara J NicklasTamara B Harris
Nov 9, 2005·International Journal of Cardiology·Julie MéthotPaul Poirier
Dec 11, 1999·Circulation Research·J P Bénitah, G Vassort

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