Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss

Diabetes/metabolism Research and Reviews
A LautenbachJ Aberle

Abstract

Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following Roux-en-Y gastric bypass (RYGB). Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis. Eleven patients were recruited in the Obesity Centre of the University Medical Centre Hamburg-Eppendorf. Before and 6 months after RYGB, total GLP-1 levels were measured during oral glucose tolerance test. To assess changes in visceral adipose tissue and pancreatic volume, MRI was performed. Measures of glucose homeostasis and insulin indices were assessed. Fractional beta-cell area was estimated by correlation with the C-peptide-to-glucose ratio; beta-cell mass was calculated by the product of beta-cell area and pancreas parenchymal weight. Pancreas volume decreased from 83.8 (75.7-92.0) to 70.5 (58.8-82.3) cm3 (mean [95% CI], P = .001). The decrease in total volume was associated with a significant decrease in fat volume. Fasting insulin and C-peptide we...Continue Reading

References

Jul 4, 2003·Current Opinion in Lipidology·Jean E Schaffer
Mar 17, 2004·Abdominal Imaging·E M GeraghtyK Jain
Nov 25, 2004·Diabetes·Ele FerranniniAndrea Mari
Aug 2, 2007·Diabetes Care·Maarten E TushuizenMichaela Diamant
Sep 20, 2007·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Y SaishoP C Butler
Mar 7, 2009·Diabetes·Matthew M Rankin, Jake A Kushner
Mar 11, 2009·The American Journal of Medicine·Henry BuchwaldIsabella Sledge
Jun 11, 2009·Diabetes·Juris J MeierHenning Schrader
Nov 3, 2009·Diabetes, Obesity & Metabolism·T Vilsbøll
Jun 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Johan BerglundJoel Kullberg
Nov 3, 2010·Annals of the New York Academy of Sciences·Jeremy A Lavine, Alan D Attie
Dec 25, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Naoaki SakataMichiaki Unno
Feb 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Mark M Smits, Erwin J M van Geenen
Aug 19, 2011·Indian Journal of Endocrinology and Metabolism·Vikas Chaudhary, Shahina Bano
Aug 10, 2012·Diabetes Care·Yoshifumi SaishoPeter C Butler
Feb 19, 2013·PloS One·Edward W SzczepaniakLidia S Szczepaniak
May 16, 2014·Advances in Nutrition·Amelia K LinnemannDawn Belt Davis
Sep 15, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Niraj S PatelRohit Loomba
Jan 18, 2015·Endocrine Connections·Nicolai J Wewer AlbrechtsenJens J Holst
Mar 4, 2015·The Journal of Clinical Endocrinology and Metabolism·Henri HonkaPirjo Nuutila
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kirstine N Bojsen-MøllerSten Madsbad

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