Adaptive changes in the responsiveness of adenylate cyclase to catecholamines

Drug and Alcohol Dependence
J P PerkinsT K Harden


Exposure of the intact astrocytoma cell to isoproterenol not only causes the activation of adenylate cyclase and the accumulation of cyclic AMP but sets in motion a complicated series of events designed to down-regulate the system if exposure to the agonist is extended in time. We have identified at least three of these processes: (1) a rapid uncoupling of the beta-receptor--adenylate cyclase system with subsequent loss of beta-receptors; (2) a slower, nonspecific desensitization of adenylate cyclase to the effects of all classes of receptor agonists by a process that may be mediated by cyclic AMP; and (3) a slow induction of phosphodiesterase activity that is probably mediated by cyclic AMP.

Related Concepts

Cyclic AMP, (R)-Isomer
Adenylate Cyclase
Adrenergic beta-Agonists
Alcohol Abuse
Mixed Oligoastrocytoma
Drug Tolerance
Enzyme Activation
Enzyme Induction

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