PMID: 3321099Jan 1, 1987Paper

Adaptive changes in thermoregulation and their neuropharmacological basis

Pharmacology & Therapeutics
K Brück, E Zeisberger

Abstract

Adaptive changes of the thermoregulatory system include morphological and functional modifications. The morphological modifications such as changes in body shape and insulation need time periods of months to years to develop, unless they are genetically fixed and appear seasonally. In general, they are preceded by functional modifications, including changes in capacity of the effector systems and changes in regulatory characteristics, which need much less time to develop. These early changes in regulatory characteristics, which can be defined as deviations in threshold and gain of the thermoregulatory responses, have been described and subdivided into short-term (minutes) and long-term (weeks) modifications. Evidence for the participation of monoaminergic brain stem systems in these modifications has been reviewed. On the basis of recent insights into the organization of the thermoregulatory system, and of evaluation of experimental evidence from electrophysiological, neuropharmacological, and neuroanatomical studies it can be concluded that these systems are involved in adaptive modifications. Receiving information from several sensory systems they seem to deliver additional modulatory signals, which may interfere with the pro...Continue Reading

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