PMID: 11335069May 4, 2001Paper

Adaptive changes in withdrawal reflexes after noxious stimulation at the heel and the toes in the decerebrated rabbit

Neuroscience Letters
R W ClarkeJ Harris

Abstract

In decerebrated rabbits, reflexes evoked by electrical stimulation of the toes in the ankle flexor tibialis anterior were enhanced for > 30 min after application of 20% mustard oil to the base of the toes, whereas responses of the ankle extensor medial gastrocnemius to stimulation of the heel were depressed for > 20 min by the same stimulus. Applied to the heel, mustard oil had inconsistent effects on the flexor reflex but potentiated the extensor response for approximately 1 h. Intrathecal co-administration of naloxone (25 microg) with the selective alpha(2)-adrenoceptor antagonist RX 821002 (200 microg) enhanced both reflexes to more than twice pre-drug values and reduced or abolished all effects of mustard oil. These data confirm that the location of a noxious stimulus is an important determinant of the subsequent adaptive changes in reflexes, and indicate roles for endogenous opioids and noradrenaline in these processes.

References

Sep 28, 1998·The European Journal of Neuroscience·J Sandkühler, X Liu
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M O Urban, G F Gebhart

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Citations

May 3, 2006·American Journal of Veterinary Research·Alessandra BergadanoClaudia Spadavecchia
May 26, 2004·Brain Research·Sarah JenkinsRob W Clarke
Oct 7, 2004·Brain Research. Brain Research Reviews·Rob W Clarke, John Harris
Jan 3, 2006·Progress in Neurobiology·Giorgio SandriniJean Claude Willer
Aug 15, 2002·CNS Drug Reviews·R W Clarke, J Harris

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