Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae

Evolutionary Applications
Benoît S AssogbaPierrick Labbé

Abstract

While gene copy-number variations play major roles in long-term evolution, their early dynamics remains largely unknown. However, examples of their role in short-term adaptation are accumulating: identical repetitions of a locus (homogeneous duplications) can provide a quantitative advantage, while the association of differing alleles (heterogeneous duplications) allows carrying two functions simultaneously. Such duplications often result from rearrangements of sometimes relatively large chromosome fragments, and even when adaptive, they can be associated with deleterious side effects that should, however, be reduced by subsequent evolution. Here, we took advantage of the unique model provided by the malaria mosquito Anopheles gambiae s.l. to investigate the early evolution of several duplications, heterogeneous and homogeneous, segregating in natural populations from West Africa. These duplications encompass ~200 kb and 11 genes, including the adaptive insecticide resistance ace-1 locus. Through the survey of several populations from three countries over 3-4 years, we showed that an internal deletion of all coamplified genes except ace-1 is currently spreading in West Africa and introgressing from An. gambiae s.s. to An. coluz...Continue Reading

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Citations

Jan 22, 2021·PLoS Genetics·Xavier Grau-BovéUNKNOWN Anopheles gambiae 1000 Genomes Consortium
Sep 5, 2021·Pest Management Science·David G Heckel

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Methods Mentioned

BETA
PCR

Software Mentioned

LightCycler ® 480
R
QuantaSoft reader

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