Adaptive denoising for chemical exchange saturation transfer MR imaging

NMR in Biomedicine
Johannes BreitlingMoritz Zaiss

Abstract

High image signal-to-noise ratio (SNR) is required to reliably detect the inherently small chemical exchange saturation transfer (CEST) effects in vivo. In this study, it was demonstrated that identifying spectral redundancies of CEST data by principal component analysis (PCA) in combination with an appropriate data-driven extraction of relevant information can be used for an effective and robust denoising of CEST spectra. The relationship between the number of relevant principal components and SNR was studied on fitted in vivo Z-spectra with artificially introduced noise. Three different data-driven criteria to automatically determine the optimal number of necessary components were investigated. In addition, these criteria facilitate straightforward assessment of data quality that could provide guidance for CEST MR protocols in terms of SNR. Insights were applied to achieve a robust denoising of highly sampled low power Z-spectra of the human brain at 3 and 7 T. The median criterion provided the best estimation for the optimal number of components consistently for all three investigated artificial noise levels. Application of the denoising technique to in vivo data revealed a considerable increase in image quality for the amid...Continue Reading

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Citations

Dec 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix GlangMoritz Zaiss
May 10, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sebastian MuellerMoritz Zaiss
Feb 23, 2020·NMR in Biomedicine·Johannes BreitlingSteffen Goerke
Jul 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lin ChenJiadi Xu
Mar 7, 2020·NMR in Biomedicine
Feb 16, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steffen GoerkePeter Bachert
Mar 25, 2021·NeuroImage·Alexander GermanFrederik Bernd Laun
Mar 28, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ran SuiJiadi Xu
May 8, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai HerzMoritz Zaiss
Aug 13, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martina CapozzaSilvio Aime
Sep 18, 2021·Current Opinion in Oncology·Lucia Nichelli, Stefano Casagranda

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