Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes

Scientific Reports
Shengdi LiGuohui Ding

Abstract

Hepatitis B virus (HBV) is classified into several genotypes, correlated with different geographic distributions, clinical outcomes and susceptible human populations. It is crucial to investigate the evolutionary significance behind the diversification of HBV genotypes, because it improves our understanding of their pathological differences and pathogen-host interactions. Here, we performed comprehensive analysis of HBV genome sequences collected from public database. With a stringent criteria, we generated a dataset of 2992 HBV genomes from eight major genotypes. In particular, we applied a specified classification of non-synonymous and synonymous variants in overlapping regions, to distinguish joint and independent gene evolutions. We confirmed the presence of selective constraints over non-synonymous variants in consideration of overlapping regions. We then performed the McDonald-Kreitman test and revealed adaptive evolutions of non-synonymous variants during genotypic differentiation. Remarkably, we identified strong positive selection that drove the differentiation of PreS1 domain, which is an essential regulator involved in viral transmission. Our study presents novel evidences for the adaptive evolution of HBV genotypes,...Continue Reading

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May 23, 2018·Biotechnology & Genetic Engineering Reviews·Shivali S Joshi, Carla S Coffin
Feb 26, 2020·Antimicrobial Agents and Chemotherapy·Jan Martin BerkeFrederik Pauwels
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Oct 13, 2020·Frontiers in Immunology·Saeed MobiniElham Rismani
Jun 11, 2021·Frontiers in Microbiology·Stephen A LocarniniLilly K W Yuen
Jul 3, 2021·Viruses·Marina Campos-ValdezLaura V Sánchez-Orozco
Mar 10, 2018·ACS Infectious Diseases·Harshana S De Silva FeelixgeKeith R Jerome

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Methods Mentioned

BETA
genotyping
PCA

Software Mentioned

BioEdit
house
ClustalW
R
MEGA5
jpHMM
MPI
DnaSP
BLASTN

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