Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals

Blood
Thomas LuftAnthony D Ho

Abstract

Phenotypic maturation, cytokine secretion, and migration are distinct functional characteristics of dendritic cells (DCs). These functions are independently regulated by a number of extracellular variables, such as type, strength, and persistence of an array of soluble and membrane-bound mediators. Since the exact composition of these variables in response to infection may differ between individuals, the intracellular signaling pathways activated by these extracellular networks may more closely correlate with DC function and predict the course of adaptive immunity. We found that activation of p38 kinase (p38K), extracellular signal-related kinase 1/2 (ERK1/2), and phosphatidylcholine-specific phospholipase C (PC-PLC) enhanced cytokine secretion, whereas p38K, cyclic adenosine monophosphate (cAMP), and PC-PLC enhanced migration. In contrast, phosphatidylinositol 3-kinase (PI3K)/Akt-1 and cAMP inhibited cytokine secretion while ERK1/2 inhibited migration. Migration and cytokine secretion further differed in their sensitivity to inhibition over time. However, although DCs could be manipulated to express migration, cytokine secretion, or both, the level of activation or persistence of intracellular pathway signaling was not predict...Continue Reading

References

Jan 1, 1996·Cancer Chemotherapy and Pharmacology·K HoffmanG N Hortobagyi
Oct 1, 1996·Molecular and Cellular Biology·H MischakW Kolch
Jun 1, 1997·Nature Biotechnology·F C Szoka
Dec 10, 1998·International Immunology·A SnijdersM L Kapsenberg
Jun 28, 2000·The Journal of Biological Chemistry·K L GuanA B Vojtek
Jul 10, 2001·The Journal of Biological Chemistry·H P ReuschK Moelling
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas LuftEugene Maraskovsky
Jan 10, 2002·The EMBO Journal·Amardeep S DhillonWalter Kolch
Jan 24, 2002·Molecular Cell·John M Schmitt, Philip J S Stork
Apr 6, 2002·International Immunology·Thomas LuftEugene Maraskovsky
Jun 6, 2002·The Journal of Biological Chemistry·Karin MoellingMarc Schweneker
Aug 3, 2002·Nature Immunology·Taro FukaoShigeo Koyasu
Aug 31, 2002·Science·E RavaszA L Barabási
Oct 26, 2002·Science·Zoltán N Oltvai, Albert-László Barabási
Oct 31, 2002·The Journal of Investigative Dermatology·Eva BuentkeAnnika Scheynius
Jul 16, 2003·Trends in Immunology·Taro Fukao, Shigeo Koyasu
Sep 1, 2004·Springer Seminars in Immunopathology·Gwendalyn J RandolphVeronique Angeli
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk StrumbergSiegfried Seeber
Jun 24, 2006·The Biochemical Journal·Thorsten FritziusKarin Moelling

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Citations

Sep 22, 2010·Pflügers Archiv : European journal of physiology·Anand RotteFlorian Lang
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ekaterina ShumilinaFlorian Lang
Dec 22, 2011·Journal of Biomedicine & Biotechnology·Jian NingDerwood Pamphilon
Aug 25, 2009·Trends in Immunology·Rieneke van de VenTanja D de Gruijl
Mar 10, 2011·NMR in Biomedicine·Franca PodoEgidio Iorio
Apr 28, 2007·Cytotherapy·D S Ritchie
Oct 18, 2005·Advances in Immunology·Francesca GranucciPaola Ricciardi-Castagnoli
Jan 31, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William K DeckerElizabeth J Shpall
Oct 5, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Lilija MillerZoe Waibler
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lianne van de LaarAndrea M Woltman
Feb 6, 2019·Frontiers in Immunology·Thiago A PatenteJosé A M Barbuto
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola CappelloMirella Giovarelli
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracey A StephensBhagirath Singh
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Loredana FrascaClara Maria Ausiello
Oct 21, 2020·Biomolecules·Robert M SchilkeMatthew D Woolard
Nov 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sascha DietrichThomas Luft
Jun 3, 2021·International Journal of Molecular Sciences·Silvia CarloniMassimiliano Petrini

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