Adaptive inducibility of CREM as transcriptional memory of circadian rhythms

Nature
N S FoulkesP Sassone-Corsi

Abstract

The CREM gene encodes the transcriptional repressor ICER, which has been implicated in the molecular mechanisms controlling circadian rhythms in mammals. ICER is rhythmically expressed in the pineal gland, with peak levels occurring at night. ICER levels are regulated by light by means of the suprachiasmatic nucleus (SCN); transcription is induced during darkness by adrenergic input to the pineal gland from the SCN, which activates the ICER promoter using cyclic AMP and the transcriptional activator CREB. This induction is transient because ICER represses its own transcription. Here we show that the response of the CREM gene to adrenergic stimulation is determined by night length. Depending on the photoperiod of the prior entraining cycles, the CREM gene is either subsensitive or supersensitive to induction. This differential responsiveness is controlled by the changing balance between positive (CREB) and negative (ICER) transcriptional regulators. Thus, the transcriptional response of the CREM gene is determined by the memory of past photoperiods.

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J A RomeroJ Axelrod
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J A Romero, J Axelrod
Jun 28, 1974·Science·J Axelrod
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi, J Axelrod
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi, J Axelrod
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L MonacoP Sassone-Corsi
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·E Lalli, P Sassone-Corsi
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SumováH Illnerová
Feb 1, 1994·Current Biology : CB·J S Takahashi
Jan 1, 1995·Annual Review of Cell and Developmental Biology·P Sassone-Corsi

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Citations

Mar 30, 2004·Brain Research. Molecular Brain Research·Lydia EngelRainer Spessert
Nov 5, 1997·Trends in Neurosciences·N S FoulkesP Sassone-Corsi
Apr 3, 2003·Brain Research. Molecular Brain Research·Elena DiazValérie Simonneaux
Jun 10, 1998·Biology of the Cell·N S FoulkesP Sassone-Corsi
Mar 23, 2000·Progress in Neurobiology·J C HendricksA I Pack
Dec 9, 1996·Biochimica Et Biophysica Acta·N S Foulkes, P Sassone-Corsi
Nov 13, 1998·Current Opinion in Neurobiology·X LiS H Snyder
Oct 3, 2002·Journal of Neurochemistry·F GuillaumondA M François-Bellan
Dec 24, 2008·The Journal of Biological Chemistry·Michael J BaileyDavid C Klein
Jun 6, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Nick A Ciccone, Ursula B Kaiser
Jan 1, 1996·Annual Review of Genetics·J C Dunlap
Aug 26, 1998·Annual Review of Nutrition·P B DanielJ F Habener
Jan 24, 2008·PloS One·Reeta RintamäkiJouko Lönnqvist
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·R MaldonadoC Mazucchelli
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MessagerP J Morgan
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·N S FoulkesP Sassone-Corsi
Feb 19, 1999·Chronobiology International·D Staiger, C Heintzen
May 12, 2006·Chronobiology International·Valérie SimonneauxPaul Pévet
May 31, 2011·Progress in Neurobiology·Michelle R Lyons, Anne E West
Jun 25, 2009·Journal of Neuroendocrinology·A SalingreV Simonneaux
Jan 17, 2004·Acta Psychiatrica Scandinavica·T PartonenJ Lönnqvist
May 6, 2004·Brain Research·Alfonso AbizaidTamas L Horvath
Oct 29, 1998·Medical Hypotheses·T Partonen
Sep 26, 2012·Chronobiology International·Evan E RaiewskiMichael R Gorman
May 7, 1999·Neuron·M P BelvinJ C Yin
Mar 25, 2004·Journal of Biological Rhythms·Ying TanTill Roenneberg
Apr 29, 1998·Journal of Biological Rhythms·T Roenneberg, M Merrow
Feb 12, 2019·Scientific Reports·Eva VarejkovaJaromir Myslivecek
Sep 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias D SeidlFrank U Müller
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Laure GaridouValerie Simonneaux
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Aug 8, 1998·The Journal of Biological Chemistry·X WuC T McMurray
Feb 7, 1998·The Journal of Biological Chemistry·M L ShinoharaJ C Dunlap

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