Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth

Journal of the Royal Society, Interface
Marie LevakovaRyota Kobayashi

Abstract

In order to understand how olfactory stimuli are encoded and processed in the brain, it is important to build a computational model for olfactory receptor neurons (ORNs). Here, we present a simple and reliable mathematical model of a moth ORN generating spikes. The model incorporates a simplified description of the chemical kinetics leading to olfactory receptor activation and action potential generation. We show that an adaptive spike threshold regulated by prior spike history is an effective mechanism for reproducing the typical phasic-tonic time course of ORN responses. Our model reproduces the response dynamics of individual neurons to a fluctuating stimulus that approximates odorant fluctuations in nature. The parameters of the spike threshold are essential for reproducing the response heterogeneity in ORNs. The model provides a valuable tool for efficient simulations of olfactory circuits.

References

Jan 1, 1987·Annals of the New York Academy of Sciences·K E KaisslingE R Rumbo
Mar 1, 1996·Journal of Computational Neuroscience·J P RosparsA Vermeulen
Jan 1, 1997·Annual Review of Neuroscience·J G Hildebrand, G M Shepherd
Jan 14, 1999·Bio Systems·P Lánský, J P Rospars
Apr 24, 2001·Journal of Computational Neuroscience·Y H Liu, X J Wang
Sep 6, 2001·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·X Gu
Mar 26, 2003·The Journal of Experimental Biology·Jan DolzerMonika Stengl
Mar 29, 2003·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·A V Minor, K-E Kaissling
May 17, 2003·Journal of Neurophysiology·Alexander RauchStefano Fusi
Aug 9, 2003·Chemical Senses·Jean-Pierre RosparsVlastimil Krivan
Mar 1, 1965·Biophysical Journal·R B STEIN
Jul 23, 2004·Chemical Senses·Karl-Ernst Kaissling, Jean-Pierre Rospars
Jul 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel P DoughertyAlice C Yew
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xavier GrosmaitreMinghong Ma
Apr 25, 2006·Journal of Computational Neuroscience·Renaud JolivetWulfram Gerstner
Jun 17, 2006·Annual Review of Neuroscience·Rachel I Wilson, Zachary F Mainen
Jul 20, 2006·PLoS Computational Biology·Pablo Achard, Erik De Schutter
Dec 28, 2007·Journal of Neuroscience Methods·Renaud JolivetWulfram Gerstner
Apr 26, 2008·PLoS Computational Biology·Lubomir KostalJean-Pierre Rospars
Mar 3, 2009·Neuron·Maria N GeffenMarkus Meister
Mar 21, 2009·PLoS Computational Biology·Yuqiao GuJean-Pierre Rospars
Aug 6, 2009·Journal of Computational Neuroscience·Hideaki Shimazaki, Shigeru Shinomoto
Aug 12, 2009·Frontiers in Computational Neuroscience·Ryota KobayashiShigeru Shinomoto
Aug 22, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Karl-Ernst Kaissling
Nov 13, 2009·Physical Review Letters·Jürgen Reingruber, David Holcman
Feb 5, 2010·Frontiers in Computational Neuroscience·Moritz HeliasStefan Rotter
Jan 11, 2011·Nature Neuroscience·Katherine I Nagel, Rachel I Wilson
Jan 14, 2011·Frontiers in Cellular Neuroscience·Monika Stengl
Jun 24, 2011·Journal of Computational Neuroscience·Jan WessnitzerBarbara Webb
Oct 28, 2011·Brain Research·Alexandre GrémiauxJean-Pierre Rospars
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlotta MartelliThierry Emonet
Oct 13, 2015·PLoS Computational Biology·Tiffany KeeMaxim Bazhenov
Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Li-Hui CaoDong-Gen Luo

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Citations

Dec 4, 2019·PLoS Computational Biology·Tomas Barta, Lubomir Kostal
Mar 20, 2021·Physical Review. E·Tomas Barta, Lubomir Kostal
Oct 15, 2021·ELife·Auguste SchulzJulijana Gjorgjieva

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