PMID: 18720722Aug 30, 2008Paper

Adaptive mechanisms of circulatory systems in children with pulmonary hypertension syndrome in congenital valvular defect

Patologicheskaia fiziologiia i èksperimental'naia terapiia
L S Vvedenskaia, V I Gorbachev

Abstract

To evaluate the condition of the nitrogen oxide system and adaptation reserves in children with pulmonary hypertension syndrome and congenital heart disease, we examined 64 patients aged 3 to 17 years. The examination included standard cardiological tests, measurements of nitrogen oxide metabolites in blood, the activity of oxidant and antioxidant systems. Blood pressure in the right ventricle and pulmonary artery was controlled by invasive (catheterization of heart cavities, monitoring with Swan-Ganz catheter) and noninvasive (ultrasound) methods. We came to the conclusion that the level of nitrogen oxide is associated with the severity of pulmonary hypertension and characterizes the condition of the oxidant and antioxidant systems.

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.