Adaptive models for gene networks.

PloS One
Yong-Jun ShinXiling Shen

Abstract

Biological systems are often treated as time-invariant by computational models that use fixed parameter values. In this study, we demonstrate that the behavior of the p53-MDM2 gene network in individual cells can be tracked using adaptive filtering algorithms and the resulting time-variant models can approximate experimental measurements more accurately than time-invariant models. Adaptive models with time-variant parameters can help reduce modeling complexity and can more realistically represent biological systems.

References

Aug 28, 1997·Oncogene·J PietteV Maréchal
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Lev Bar-OrM Oren
Dec 1, 2000·Nature·B VogelsteinA J Levine
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
Jun 15, 2006·Molecular Systems Biology·Naama Geva-ZatorskyUri Alon
Jan 4, 2008·Nature·Ivan N ColalucaPier Paolo Di Fiore
Aug 19, 2008·BMC Systems Biology·Carole J Proctor, Douglas A Gray
Oct 30, 2008·Cell·Arjun Raj, Alexander van Oudenaarden
Apr 17, 2009·Nature Reviews. Microbiology·James C W Locke, Michael B Elowitz
Sep 25, 2009·Nature Reviews. Cancer·Arnold J Levine, Moshe Oren
Mar 12, 2010·PLoS Computational Biology·Gabriele Lillacci, Mustafa Khammash
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Naama Geva-ZatorskyUri Alon
Nov 8, 2011·Nature Biotechnology·Andreas Milias-ArgeitisJohn Lygeros

❮ Previous
Next ❯

Citations

Sep 3, 2013·BMC Systems Biology·Yong-Jun ShinXiling Shen
Apr 23, 2016·Scientific Reports·Yong-Jun Shin
Aug 9, 2020·Frontiers in Bioengineering and Biotechnology·Laura D WeinstockLevi B Wood

❮ Previous
Next ❯

Software Mentioned

MATLAB System Identification Toolbox
LabVIEW System Identification Toolkit
LabVIEW

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.