Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients

Respiratory Research
Sergi Pascual-GuardiaJoaquim Gea

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, continuous exacerbations, alpha-1-antitrypsin deficiency and inflammatory-immune response, are involved in the pathophysiology and progression of the disease. However, the role of natural killer (NK) cells remains controversial. Otherwise, human cytomegalovirus (HCMV) infection has been reported to induce an adaptive differentiation and expansion of an NK cell subset which carries the CD94/NKG2C receptor, which may contribute to an upset immune defense. For these reasons, our objective is to assess the distribution of NK cells and their subset in COPD patients and some of its phenotypes. Peripheral blood samples were obtained from 66 COPD patients. HCMV serology and the proportions of total NK cells and the NKG2C+ and NKG2A+ subsets were evaluated by flow cytometry. The NKG2C genotype was also assessed. Eighty-eight per cent of COPD patients were HCMV(+), and the proportions of total NK cells were higher in patients with severe-very severe airway obstruction than in those with only mild-moderate involvement. There were ...Continue Reading

References

Jan 1, 1992·Respiration; International Review of Thoracic Diseases·U CostabelY M Wang
Apr 1, 1990·The American Review of Respiratory Disease·J RocaJ L Clausen
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Aug 6, 1998·Respiratory Medicine·J RocaJ L Clausen
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Jul 20, 2001·Journal of Virology·C Söderberg-NauclérJ A Nelson
Aug 12, 2004·Blood·Mónica GumáMiguel López-Botet
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Rosemary J BoytonDaniel M Altmann
May 25, 2007·Clinical and Experimental Immunology·R J Boyton, D M Altmann
Sep 8, 2007·Respiratory Research·Mathieu C MorissetteJulie Milot
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
Mar 14, 2008·Clinical Science·Lucy FaircloughJonathan R Lamb
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Jul 9, 2008·Medical Mycology·R J Boyton
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Feb 7, 2009·The Journal of Clinical Investigation·Michael T BorchersMauricio Orozco-Levi
Jun 24, 2009·Respiratory Research·Richard A UrbanowiczLucy C Fairclough
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory T MotzMichael T Borchers
Jun 15, 2010·Respiratory Research·Richard A UrbanowiczLucy C Fairclough
Nov 2, 2011·Respiratory Medicine·Matija RijavecPeter Korosec
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian W WorthamMichael T Borchers
Oct 16, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Greg HodgeSandra Hodge
Feb 7, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M CrespoJ Pascual
Jun 29, 2016·Mechanisms of Ageing and Development·Miguel López-BotetAldi Pupuleku
Dec 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dolores Redondo-PachónMiguel López-Botet
May 17, 2017·Archivos de bronconeumología·Juan P de-Torres, Jose M Marin
Aug 27, 2017·Scientific Reports·Masaru SuzukiJames C Hogg
Apr 21, 2018·American Journal of Respiratory and Critical Care Medicine·Donna K FinchChristine M Freeman
Apr 10, 2019·Journal of Leukocyte Biology·Kayla A Holder, Michael D Grant

❮ Previous
Next ❯

Citations

May 22, 2021·Frontiers in Immunology·Yafei RaoYongchang Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
FACS
bronchoalveolar lavage

Software Mentioned

SPSS
DIVA

Related Concepts

Related Feeds

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Dolores Redondo-PachónMiguel López-Botet
The Journal of Clinical Investigation
Alexander RölleAdelheid Cerwenka
Trends in Immunology
Julia A Wagner, Todd A Fehniger
© 2021 Meta ULC. All rights reserved