Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases

Progress in Retinal and Eye Research
Michel PaquesKate Grieve

Abstract

Adaptive optics (AO)-enhanced en face retinal imaging, termed here AO ophthalmoscopy (AOO) has reached a level of robustness which fuels its increasing use in research and clinical centers. Here we will review the contribution of clinical AOO to the understanding and monitoring of 1) age-related macular degeneration and 2) vascular diseases. The main contributions of AOO to the phenotyping of AMD are a better identification of drusen, a better delineation of the limits of atrophy, and the identification of novel features such as punctate hyperreflectivity and mobile melanin-containing clumps. Characterization of progression of atrophy is facilitated by time-lapse imaging. In vessels, AOO enables the observation and measurement of parietal structures and the observation of microscopic pathological features such as small hemorrhages and inflammatory cell accumulations.

Citations

Apr 4, 2019·Ophthalmic Genetics·Vittoria MurroStanislao Rizzo
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Jul 12, 2019·Translational Vision Science & Technology·Mali OkadaAdnan Tufail
Dec 5, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Phillip Bedggood, Andrew Metha
Oct 6, 2020·Biomedical Optics Express·Pedro MecêClaude Boccara
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Serge PicaudJosé-Alain Sahel
Jun 5, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Antonio GalloXavier Girerd
Mar 31, 2021·Acta Ophthalmologica·Inês Monteiro-HenriquesJoão Barbosa-Breda
Jun 7, 2021·Survey of Ophthalmology·Elise BakkerMichel Paques
May 18, 2021·American Journal of Ophthalmology·José-Alain SahelKatia Marazova
Jun 26, 2021·Annual Review of Vision Science·Stephen A BurnsThomas J Gast
Feb 25, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Chui Ming Gemmy CheungSobha Sivaprasad
Dec 21, 2021·Translational Vision Science & Technology·Ethan A RossiMichel Paques

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