PMID: 11915926Mar 28, 2002Paper

Adaptive potentials of skeletal muscle in young and aging rats

International Journal of Sport Nutrition and Exercise Metabolism
D Pette, D Skorjanc

Abstract

We compared responses of the fast extensor digitorum longus (EDL) and tibialis anterior (TA) muscles in young (15-week) and aging (101-week) male Brown Norwegian rats to 50 days of chronic low-frequency stimulation (CLFS, 10 Hz, 10 hours/day). After 50 days of CLFS, the EDL muscles of the young (22-week) and aging (108-week) rats displayed similar increases in type IIA fibers, relative concentration of myosin heavy chain MHCIIa, elevations in mitochondrial citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities, and similar decreases in glycolytic enzyme activities (glyceraldehydephosphate dehydrogenase, lactate dehydrogenase). TA muscle in young rats contained a few cytochrome c oxidase negative (COX-) type I fibers. Their number was approximately 2-fold elevated by CLFS. Conversely, aging muscle, which contained a slightly higher amount of COX- fibers than young TA muscle, responded to CLFS with a significant decrease in COX- fibers. The appearance of small COX-positive type I fibers in stimulated aging muscle indicated that regenerating type I fibers "diluted" the COX-deficient fiber population.

Citations

Dec 5, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aude ZangarelliStéphane Walrand
Apr 10, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tanya M HollowayLawrence L Spriet
May 3, 2015·Physiology·Heather N CarterDavid A Hood
Apr 9, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Scott D Kirkton, Ariella A Yazdani

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