Adaptive protein evolution and regulatory divergence in Drosophila

Molecular Biology and Evolution
Jeffrey M GoodTravis J Wheeler

Abstract

Two recent studies demonstrated a positive correlation between divergence in gene expression and protein sequence in Drosophila. This correlation could be driven by positive selection or variation in functional constraint. To distinguish between these alternatives, we compared patterns of molecular evolution for 1,862 genes with two previously reported estimates of expression divergence in Drosophila. We found a slight negative trend (nonsignificant) between positive selection on protein sequence and divergence in expression levels between Drosophila melanogaster and Drosophila simulans. Conversely, shifts in expression patterns during Drosophila development showed a positive association with adaptive protein evolution, though as before the relationship was weak and not significant. Overall, we found no strong evidence for an increase in the incidence of positive selection on protein-coding regions in genes with divergent expression in Drosophila, suggesting that the previously reported positive association between protein and regulatory divergence primarily reflects variation in functional constraint.

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Citations

Nov 21, 2007·Journal of Molecular Evolution·Carlo G ArtieriRama S Singh
Dec 9, 2008·Genetics Research·Pranveer Singh, Bashisth N Singh
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brendan G HuntMichael A D Goodisman
Oct 31, 2007·PLoS Genetics·Alisha K HollowayCorbin D Jones
Oct 17, 2012·PLoS Genetics·Richard P MeiselAndrew G Clark
Jun 22, 2010·Biochimie·He-ping XuYu-song Xu
Sep 10, 2011·International Journal of Evolutionary Biology·Miguel GallachEsther Betrán
Oct 19, 2013·Evolution; International Journal of Organic Evolution·Genevieve M KozakAndrew Whitehead

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