Adaptive resistance in bacteria requires epigenetic inheritance, genetic noise, and cost of efflux pumps

PloS One
Santiago Sandoval MottaMaximino Aldana

Abstract

Adaptive resistance emerges when populations of bacteria are subjected to gradual increases of antibiotics. It is characterized by a rapid emergence of resistance and fast reversibility to the non-resistant phenotype when the antibiotic is removed from the medium. Recent work shows that adaptive resistance requires epigenetic inheritance and heterogeneity of gene expression patterns that are, in particular, associated with the production of porins and efflux pumps. However, the precise mechanisms by which inheritance and variability govern adaptive resistance, and what processes cause its reversibility remain unclear. Here, using an efflux pump regulatory network (EPRN) model, we show that the following three mechanisms are essential to obtain adaptive resistance in a bacterial population: 1) intrinsic variability in the expression of the EPRN transcription factors; 2) epigenetic inheritance of the transcription rate of EPRN associated genes; and 3) energetic cost of the efflux pumps activity that slows down cell growth. While the first two mechanisms acting together are responsible for the emergence and gradual increase of the resistance, the third one accounts for its reversibility. In contrast with the standard assumption, o...Continue Reading

References

Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M L BarclayS T Chambers
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L McMurryS B Levy
Oct 1, 1996·Journal of Bacteriology·H Nikaido
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B R LevinF M Stewart
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·M N Alekshun, S B Levy
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·M OethingerS B Levy
Sep 28, 1999·Trends in Microbiology·M N Alekshun, S B Levy
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Miguel ViveirosLeonard Amaral
Dec 21, 2002·The Journal of Antimicrobial Chemotherapy·M A Webber, L J V Piddock
Mar 1, 2003·BMJ : British Medical Journal·Annette Wind OlesenJorn Olsen
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anders Løbner-OlesenFlemming G Hansen
Aug 28, 2003·Evolution; International Journal of Organic Evolution·Massimo Pigliucci, Courtney J Murren
Apr 2, 2005·Current Opinion in Microbiology·Anders Løbner-OlesenMartin G Marinus
May 30, 2006·The Journal of Experimental Biology·Massimo PigliucciCarl D Schlichting
Aug 8, 2006·Current Opinion in Microbiology·Dan I Andersson
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Josep Casadesús, David Low
Feb 27, 2007·Cell·Oliver J Rando, Kevin J Verstrepen
Oct 24, 2007·Antimicrobial Agents and Chemotherapy·Patrick F McDermottStuart B Levy
Feb 20, 2008·BMC Evolutionary Biology·Mike AdamS Steven Potter
Jan 27, 2009·Biochimica Et Biophysica Acta·Klaas M Pos
Jun 3, 2009·Evolution; International Journal of Organic Evolution·Alex K Lancaster, Joanna Masel
Aug 15, 2009·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yumiko TakatsukaHiroshi Nikaido
Jun 29, 2011·FEMS Microbiology Reviews·Hiroshi Nikaido, Jean-Marie Pagès
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rutger HermsenTerence Hwa
Oct 5, 2012·Clinical Microbiology Reviews·Lucía Fernández, Robert E W Hancock
Dec 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·María Antonia Sánchez-Romero, Josep Casadesús
Jul 28, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Bryan D Schindler, Glenn W Kaatz

❮ Previous
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Citations

Jul 15, 2015·International Journal of Food Microbiology·A BridierR Briandet
Dec 16, 2017·Journal of Biophotonics·Rafig GurbanovAyse G Gozen
May 31, 2018·Angewandte Chemie·Stefano AgnelloRainer Riedl
Jul 16, 2019·FEMS Microbiology Ecology·Paula JorgeMaria Olívia Pereira
Nov 15, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Malcom G P Page
Oct 30, 2019·Journal of Molecular Evolution·Eirini ChristakiAndreas Tofarides
Apr 21, 2018·Current Drug Discovery Technologies·Jacob Peedicayil
Nov 20, 2019·Antimicrobial Agents and Chemotherapy·Dipannita GhoshPerumal Vivekanandan
Jan 26, 2020·FEMS Microbiology Reviews·Dan I AnderssonTone Tønjum
Apr 23, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Santiago Sandoval-Motta, Maximino Aldana
Jan 9, 2019·Frontiers in Physiology·Saúl HuitzilMaximino Aldana
Apr 16, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Ettore CrimiClaudio Napoli
Jun 5, 2020·Current Microbiology·Gabrielle Limeira GenteluciMaria Helena Simões Villas Bôas
Mar 20, 2019·Expert Opinion on Drug Discovery·Vladislav M ChernovRustam I Aminov
Dec 6, 2019·Frontiers in Microbiology·Aabir BanerjiScott Keely
Feb 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Wenlong Zuo, Yilin Wu
Jul 16, 2017·European Biophysics Journal : EBJ·Tahmina RahmanDeclan A Doyle
Jul 4, 2020·Biomedical Materials·Victoria M WuVuk Uskoković
Jan 9, 2021·Trends in Microbiology·Leise Riber, Lars Hestbjerg Hansen
May 16, 2020·Trends in Microbiology·Wesley Morovic, Charles R Budinoff
Jun 9, 2021·Future Microbiology·Leonora L CalsavaraKatiany R Caleffi-Ferracioli
Jun 22, 2021·Frontiers in Microbiology·María A Sánchez-Romero, Josep Casadesús

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Methods Mentioned

BETA
genetic modifications

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