Adaptive response of human melanoma cells to methylglyoxal injury

Carcinogenesis
F AmicarelliMichele Miranda

Abstract

The effects of methylglyoxal on the growth of a line of human melanoma cells are investigated. Methylglyoxal inhibits cell growth in a dose-dependent manner and causes an increase in glyceraldehyde 3-phosphate dehydrogenase, and glyoxalase 1 and glyoxalase 2 specific activities. The cellular response to increasing concentrations of methylglyoxal in the culture medium is also studied by measuring L-lactate production, reduced-oxidized glutathione levels and apoptotic cell death. Methylglyoxal seems to promote a change of cell population phenotypic repertoire toward a more monomorphic phenotype. In conclusion, methylglyoxal seems to induce an enzymatic cellular response that lowers methylglyoxal levels and selects the most resistant cells.

Citations

Feb 1, 2003·Archives of Biochemistry and Biophysics·Norbert W Seidler, Catherine Kowalewski
Oct 15, 2003·Free Radical Biology & Medicine·Fernanda AmicarelliMichele Miranda
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E MeariniV N Talesa
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May 23, 2001·Breast Cancer Research and Treatment·A RulliV Talesa
Sep 7, 2002·Antioxidants & Redox Signaling·Anwarul A AkhandIzumi Nakashima
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