PMID: 3319810Jan 1, 1987Paper

Adaptive responses to pharmacological inhibition of small intestinal alpha-glucosidases in the rat

Gut
B LembckeW Creutzfeldt

Abstract

Intestinal adaptation (small intestinal weight and length, weight of the caecum and of the residual colon) to feeding different doses (0-5-50-500 mg/kg bw) of the absorbable, competitive alpha-glucosidase inhibitors BAY m 1099 and BAY o 1248 for three, seven, or 28 days was studied in rats. With the highest dose of either inhibitor, a significant and time dependent growth of the caecum was observed. Under these conditions, caecal tissue polyamine concentrations (spermidine and spermine) were slightly higher after three, unaffected after seven and slightly decreased after 28 days. Comparing the trophic effect both of BAY m 1099 and BAY o 1248 with that of the almost unabsorbed glucosidase inhibitor acarbose in fed rats showed that caecal weight was higher in response to the absorbed compounds than in response to acarbose, while total caecal carbohydrate content was unaffected by the absorbed and about nine fold increased by the unabsorbed inhibitors. These findings suggest that acarbose may partially inhibit bacterial carbohydrate degradation in the caecum.

References

May 11, 1976·The Journal of Clinical Investigation·J H Bond, M D Levitt
Nov 1, 1985·European Heart Journal·A Jervell
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·W CreutzfeldtJ M Conlon
Dec 19, 1984·Journal of Chromatography·J A Podcasy, S G Weber

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Citations

Aug 20, 2010·Inflammatory Bowel Diseases·Stephane NanceyDominique Kaiserlian
Jan 5, 2000·European Journal of Clinical Investigation·Y Z AlmallahO Eremin
Feb 25, 2015·Journal of Medicinal Chemistry·Hongliang DuanJianhua Shen
Mar 1, 1992·World Journal of Surgery·D ArmstrongA L Blum
Sep 1, 1991·The Journal of Applied Bacteriology·H A ShoebA M Shibl
Jan 1, 1994·Microbiology and Immunology·P MuscasG Satta
Aug 1, 1994·European Journal of Clinical Investigation·A J Reuser, H A Wisselaar
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B LembckeW Creutzfeldt

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