Adaptive servo-ventilation therapy of central sleep apnoea and its effect on sleep quality

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Andrea HetzeneckerMichael Arzt

Abstract

Poor sleep quality is common in patients with chronic heart failure (CHF). This study tested the hypothesis that adaptive servo-ventilation (ASV) therapy in CHF patients whose central sleep apnoea (CSA) was not suppressed by continuous positive airway pressure (CPAP) (CPAP-non-responders) would improve sleep quality compared to CPAP-responders receiving ongoing CPAP therapy. Eighty-two patients with CHF (65 ± 9 years, left ventricular ejection fraction 35 ± 16 %) and CSA [apnoea-hypopnoea index (AHI) ≥15/h] were retrospectively studied. Within an average of 47 days, patients were reevaluated on CPAP therapy and stratified according to their suppression of CSA: 34 were CPAP-non-responders switched to ASV therapy the following day and 48 were CPAP-responders who continued on CPAP therapy. Polysomnographic parameters were assessed in the diagnostic night and on the last night of PAP therapy (CPAP or ASV) before the patient was discharged with the final pressure settings. Compared with the CPAP group, the ASV group had significantly greater reductions from baseline in AHI (-37 ± 15/h vs -28 ± 18/h, p = 0.02), arousal index (-12.7 ± 13.6/h vs -6.8 ± 12.5/h, p = 0.04) and sleep stage N1 (-9 ± 14 % vs -2 ± 12 %, p = 0.03). In addition...Continue Reading

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Citations

May 14, 2016·Nature Reviews. Cardiology·Gianfranco ParatiUNKNOWN Italian Society of Cardiology (SIC) Working Group on Heart Failure members
Apr 9, 2017·Sleep & Breathing = Schlaf & Atmung·Anke TüroffOlaf Oldenburg
Jan 27, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Katharina HeiderMaximilian Valentin Malfertheiner
Dec 6, 2017·ERJ Open Research·Winfried RanderathRami Khayat
Apr 11, 2018·Der Internist·H WoehrleM Arzt
Dec 5, 2019·The Cochrane Database of Systematic Reviews·Shuhei YamamotoRintaro Mori
Jun 27, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kamila LachowskaDagmara Hering
Apr 19, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Maximilian V MalfertheinerM Arzt
Sep 4, 2020·Sleep & Breathing = Schlaf & Atmung·Leonie KolbMaximilian Malfertheiner

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