Adaptive shaping of cortical response selectivity in the vibrissa pathway

Journal of Neurophysiology
He J V ZhengGarrett B Stanley

Abstract

One embodiment of context-dependent sensory processing is bottom-up adaptation, where persistent stimuli decrease neuronal firing rate over hundreds of milliseconds. Adaptation is not, however, simply the fatigue of the sensory pathway, but shapes the information flow and selectivity to stimulus features. Adaptation enhances spatial discriminability (distinguishing stimulus location) while degrading detectability (reporting presence of the stimulus), for both the ideal observer of the cortex and awake, behaving animals. However, how the dynamics of the adaptation shape the cortical response and this detection and discrimination tradeoff is unknown, as is to what degree this phenomenon occurs on a continuum as opposed to a switching of processing modes. Using voltage-sensitive dye imaging in anesthetized rats to capture the temporal and spatial characteristics of the cortical response to tactile inputs, we showed that the suppression of the cortical response, in both magnitude and spatial spread, is continuously modulated by the increasing amount of energy in the adapting stimulus, which is nonuniquely determined by its frequency and velocity. Single-trial ideal observer analysis demonstrated a tradeoff between detectability and...Continue Reading

References

May 1, 1978·Journal of Neurophysiology·D J Simons
Jan 1, 1992·Trends in Neurosciences·M A Goodale, A D Milner
Mar 1, 1992·Cerebral Cortex·C J Lee, B L Whitsel
Dec 1, 1970·Physiology & Behavior·C J Vierck, M B Jones
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F Crick
Jan 1, 1995·Somatosensory & Motor Research·G E Carvell, D J Simons
Jan 1, 1993·The Journal of the Acoustical Society of America·A K Goble, M Hollins
Feb 21, 1998·Journal of Neurophysiology·B R ShethM Sur
Feb 9, 1999·Neural Computation·A PougetP E Latham
Feb 9, 1999·Neural Computation·L F Abbott, P Dayan
Apr 15, 1999·Annual Review of Neuroscience·J D Schall, K G Thompson
Oct 26, 1999·Trends in Neurosciences·C I MooreM Sur
Feb 13, 2001·Trends in Cognitive Sciences·J I. Gold, M N. Shadlen
Feb 13, 2001·Trends in Neurosciences·S M Sherman
Mar 29, 2001·Nature Neuroscience·S M Sherman
Aug 24, 2001·Nature·A L FairhallR R de Ruyter Van Steveninck
Sep 24, 2002·Nature Neuroscience·Erik P Cook, John H R Maunsell
Oct 25, 2003·Cerebral Cortex·Mark E MazurekMichael N Shadlen
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carl C H PetersenBert Sakmann
Dec 26, 2003·Journal of Neurophysiology·Roxanna M Webber, Garrett B Stanley
Mar 24, 2004·Trends in Neurosciences·Philip L Smith, Roger Ratcliff
May 12, 2004·Journal of Neurophysiology·Christopher I Moore
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ehsan ArabzadehMathew E Diamond
Oct 22, 2004·Journal of Neurophysiology·Valérie Ego-StengelDaniel E Shulz
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas A Lesica, Garrett B Stanley
Jan 22, 2005·PLoS Biology·Ehsan ArabzadehMathew E Diamond
Jun 23, 2005·BMC Neuroscience·Stephen B SimonsMark Tommerdahl
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander C Huk, Michael N Shadlen
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J Higley, Diego Contreras
Feb 10, 2006·Journal of Neurophysiology·Roxanna M Webber, Garrett B Stanley
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ali-Reza Boloori, Garrett B Stanley
Apr 18, 2006·Nature Neuroscience·Sylvain Crochet, Carl C H Petersen
Jun 8, 2006·PLoS Biology·Nicholas A LesicaGarrett B Stanley
Jun 9, 2006·Nature Reviews. Neuroscience·Bruno B AverbeckAlexandre Pouget
Jun 30, 2006·Brain Research·Vinay TannanMark A Tommerdahl
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maik C StüttgenCornelius Schwarz
Oct 24, 2006·Nature Neuroscience·Yuzhi ChenEyal Seidemann

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Citations

Jan 19, 2016·Cell Reports·Clarissa J WhitmireGarrett B Stanley
Oct 21, 2016·Neuron·Clarissa J Whitmire, Garrett B Stanley
Oct 21, 2016·Journal of Neurophysiology·Clarissa J WhitmireGarrett B Stanley
Dec 2, 2017·PLoS Computational Biology·Vincent JacobPhilippe Lucas
Dec 7, 2016·Neurophotonics·Alexandros KyriakatosCarl C H Petersen

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