Adaptive template generation for amyloid PET using a deep learning approach

Human Brain Mapping
Seung Kwan KangJae Sung Lee

Abstract

Accurate spatial normalization (SN) of amyloid positron emission tomography (PET) images for Alzheimer's disease assessment without coregistered anatomical magnetic resonance imaging (MRI) of the same individual is technically challenging. In this study, we applied deep neural networks to generate individually adaptive PET templates for robust and accurate SN of amyloid PET without using matched 3D MR images. Using 681 pairs of simultaneously acquired 11 C-PIB PET and T1-weighted 3D MRI scans of AD, MCI, and cognitively normal subjects, we trained and tested two deep neural networks [convolutional auto-encoder (CAE) and generative adversarial network (GAN)] that produce adaptive best PET templates. More specifically, the networks were trained using 685,100 pieces of augmented data generated by rotating 527 randomly selected datasets and validated using 154 datasets. The input to the supervised neural networks was the 3D PET volume in native space and the label was the spatially normalized 3D PET image using the transformation parameters obtained from MRI-based SN. The proposed deep learning approach significantly enhanced the quantitative accuracy of MRI-less amyloid PET assessment by reducing the SN error observed when an aver...Continue Reading

References

Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jul 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Dong Young LeeJong In Woo
Dec 14, 2007·Clinical Nuclear Medicine·Ryan D NiederkohrAndrew Quon
Jan 18, 2012·NeuroImage·Alan C EvansSylvain Baillet
Nov 19, 2013·The Journal of General Virology·Lucy G Thorne, Ian G Goodfellow
Jun 16, 2014·Current Opinion in Neurobiology·Kristina Simonyan
Jul 22, 2014·NeuroImage·Heung-Il SukUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 6, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C-Y ChangK-C Huang
Dec 25, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hyun Joon AnJae Sung Lee
Jan 1, 2016·Deep Learning and Data Labeling for Medical Applications : First International Workshop, LABELS 2016, and Second International Workshop, DLMIA 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 21, 2016, Proceedings·Dong NieDinggang Shen
Aug 31, 2017·Biomedical Engineering Letters·Romany F Mansour
Jan 4, 2019·Biomedical Engineering Letters·Debangshu DeySugata Munshi

❮ Previous
Next ❯

Citations

Jun 25, 2019·Nuclear Medicine and Molecular Imaging·Dong Soo Lee
May 8, 2020·Nuclear Medicine and Molecular Imaging·Arun GuptaJae Sung Lee
Jan 20, 2021·Scientific Reports·Seung Kwan KangJae Sung Lee
Jan 30, 2021·Seminars in Nuclear Medicine·Gaspar DelsoPatrick Veit-Haibach
Feb 23, 2021·NeuroImage·Seung Kwan KangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Hossein ArabiHabib Zaidi
Apr 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jordi PeguerolesUNKNOWN Australian Imaging, Biomarkers and Lifestyle Research Group
Mar 30, 2021·Physics in Medicine and Biology·Seung Kwan Kang, Jae Sung Lee
Apr 29, 2021·Physics in Medicine and Biology·Donghwi HwangJae Sung Lee
Aug 6, 2021·Biomedical Engineering Letters·Seung Kwan KangJae Sung Lee
Aug 6, 2021·Radiology. Artificial Intelligence·Nicholas JosselynWalter R Witschey
Apr 7, 2021·Journal of Nuclear Medicine Technology·Yuma TsubakiUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative
Jan 15, 2022·Annals of Nuclear Medicine·Satoshi Minoshima, Donna Cross
Jan 15, 2022·Annals of Nuclear Medicine·Keisuke MatsubaraYuichi Kimura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

© 2022 Meta ULC. All rights reserved