Adaptive time management for patients who have non-small cell lung cancer and underwent definitive radiotherapy: a dosimetric study of different gap duration scenarios.

International Journal of Radiation Biology
Aysun Inal, Evrim Duman

Abstract

The purpose of this study was to evaluate the tumor control probability (TCP), normal tissue complication probability (NTCP) and adaptive time management (ATM) in patients who had non-small cell lung cancer (NSCLC) and underwent radiotherapy with same gap length at different treatment weeks. Twenty patients' definitive radiotherapy treatments, completed in 6.5 weeks, were evaluated retrospectively. Three different scenarios with gaps in 5 fractions at different weeks of treatment (2nd, 4th, and 6th week) were planned. Three ATM models (biologically effective dose (CBED), time-dose-fractionation (CTDF) and in-house developed (CInH)) were calculated for each scenario. TCP and NTCP were calculated and compared with the dose-volume histogram (DVH) of each model. TCP was accepted as 100% in uninterrupted treatments. When treatment was interrupted and not compensated with ATM, the highest TCP difference was determined as 23.46% in the 4th week (p<.001). Based on comparisons of ATM models, the lowest TCP decrease was found in CInH. Increasing the fraction size by CInH and CBED provided more TCP improvement than increasing the number of fractions by CTDF. The treatment gap to be given in the middle of the treatment is more challenging ...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·C BurmanM Goitein
Mar 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C G Orton, L Cohen
Jan 1, 1984·Acta Radiologica. Oncology·A Brahme
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·J H HendryA G Robertson
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, R Chappell
Mar 8, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M ChenT F Liu
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M MehtaJ Fowler
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Rafal TarnawskiAndrzej Wygoda
Jan 31, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·R G DaleJ A Sinclair
May 20, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Maciá I GarauM Peraire Llopis
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Lawrence B MarksJoseph O Deasy
Jul 7, 2010·The British Journal of Radiology·J F Fowler
Dec 12, 2012·Radiation Oncology·Paul Martin PutoraLudwig Plasswilm
Nov 10, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·José A González FerreiraBranislav Jeremic
Jul 20, 2017·International Journal of Radiation Oncology, Biology, Physics·Matthew T McMillanCharles B Simone
Mar 13, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Gustavo PozoJose Fermin Pérez-Regadera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.