Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells.

Frontiers in Neuroscience
A PanossianAlexzander Asea

Abstract

The beneficial stress-protective effect of adaptogens is related to the regulation of homeostasis via mechanisms of action associated with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of the stress response, such as molecular chaperones, stress-activated c-Jun N-terminal protein kinase, forkhead box O transcription factor, cortisol, and nitric oxide (NO). However, it still remains unclear what the primary upstream targets are in response to stimulation by adaptogens. The present study addresses this gap in our knowledge and suggests that an important target for adaptogen mediated stress-protective effector functions is the stress hormone neuropeptide Y (NPY). We demonstrated that ADAPT-232, a fixed combination of adaptogens Eleutherococcus senticosus root extract, Schisandra chinensis berry extract, Rhodiola rosea root extract SHR-5, and its active constituent salidroside, stimulated the expression of NPY and 72 kDa heat shock protein (Hsp72) in isolated human neuroglia cells. The central role of NPY was validated in experiments in which pre-treatment of human neuroglia cells with NPY-siRNA and HSF1-siRNA resulted in the significant suppression of ADAPT-232-induced NPY and Hsp72 release. Taken tog...Continue Reading

Citations

Sep 22, 2012·Journal of Obesity·Maria Vittoria Micioni Di BonaventuraCarlo Cifani
Aug 8, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rosa Mariana Montiel-RuizMyrna Déciga-Campos
Aug 8, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexzander AseaKarl Georg Wikman
Feb 11, 2015·Climacteric : the Journal of the International Menopause Society·F H Comhaire, H T Depypere
Feb 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A PanossianH Wagner
Mar 30, 2013·The Psychiatric Clinics of North America·Alexander G Panossian
Aug 28, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C MannucciG Calapai
Sep 24, 2015·Andrologia·F Comhaire, A Mahmoud
Mar 26, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jay D Amsterdam, Alexander G Panossian
Aug 31, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander PanossianThomas Efferth
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sagrario Martín-AragónPaloma Bermejo-Bescós
Jul 13, 2020·Journal of Neurochemistry·Courtney M ClarkTracey C Dickson
Sep 12, 2020·Pharmaceuticals·Alexander Panossian, Thomas Brendler
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Swati Sahoo, Brijesh S
Feb 2, 2019·Aging and Disease·Wei ZhuangYumin Luo

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Datasets Mentioned

BETA
LO7577

Methods Mentioned

BETA
nuclear translocation
Assay
Enzyme
transfection
flow cytometry
ELISA

Software Mentioned

GraphPad
BIOSOFT
ASSAYZAP
Prism
Effi Validation
AAB
Oligoengine

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