Adaptor proteins GIR1 and GIR2. II. Interaction with the co-repressor TOPLESS and promotion of histone deacetylation of target chromatin

Biochemical and Biophysical Research Communications
Renhong Wu, Vitaly Citovsky

Abstract

Understanding how root hair development is controlled is important for understanding of many fundamental aspects of plant biology. Previously, we identified two plant-specific adaptor proteins GIR1 and GIR2 that interact with the major regulator of root hair development GL2 and suppress formation of root hair. Here, we show that GIR1 and GIR2 also interact with the co-repressor TOPLESS (TPL). This interaction required the GIR1 protein EAR motif, and was essential for the transcriptional repressor activity of GIR1. Both GIR1 and GIR2 promoted histone hypoacetylation of their target chromatin. Potentially, GIR1 and GIR2 might may link TPL to and participate in epigenetic regulation of root hair development.

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May 21, 2017·Biochemical and Biophysical Research Communications·Renhong Wu, Vitaly Citovsky

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Citations

Apr 3, 2019·International Journal of Molecular Sciences·Purnima SinghPinky Agarwal
Jan 29, 2020·Journal of Experimental Botany·Min-Liang WuHong Cui
Oct 12, 2019·International Journal of Molecular Sciences·Siyu Chen, Shucai Wang
Dec 18, 2018·Frontiers in Genetics·Jiaotong YangZhen Su

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