Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation

Trends in Immunology
Juan Rivera

Abstract

The Fc epsilonRI-dependent activation of nuclear factor (NF)kappaB is key for mast-cell cytokine production. The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes. A recent study reveals that the Bcl10-Malt1 complex promotes mast-cell interleukin-6 and tumor necrosis factor production, independent of degranulation, eicosanoid secretion or survival. The new findings place this complex at the forefront in discriminating between signals required for cytokine production and those required for mast-cell degranulation and eicosanoid production.

References

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W McKeithan
Nov 5, 2002·Current Opinion in Immunology·Juan Rivera
Aug 12, 2003·Trends in Immunology·Margot Thome, Jürg Tschopp
May 4, 2004·Nature Reviews. Immunology·Margot Thome
Oct 2, 2004·Nature Reviews. Immunology·Jean S Marshall
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Dec 17, 2005·Immunity·Daniel Rueda, Margot Thome
Dec 17, 2005·Immunity·Karen SommerDavid J Rawlings

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Citations

Oct 22, 2009·International Archives of Allergy and Immunology·Janet M OliverMark Schuyler
Apr 3, 2007·Trends in Immunology·Martin Metz, Marcus Maurer
Sep 17, 2009·Immunological Reviews·Yoshihiro Baba, Tomohiro Kurosaki
Nov 17, 2009·Immunological Reviews·Damiana Alvarez-ErricoJuan Rivera
Nov 17, 2007·Cellular Microbiology·Diletta ArcidiaconoMarina de Bernard
May 15, 2007·Immunological Reviews·Theoharis C TheoharidesDimitris Kalogeromitros
May 15, 2007·Immunological Reviews·Juan Rivera, Ana Olivera
Dec 28, 2010·Biochimica Et Biophysica Acta·Theoharis C TheoharidesDimitrios Kalogeromitros
Mar 26, 2020·PloS One·Patricia A A BuranelloConstance Oliver
Apr 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joon Hyun KwonIck Young Kim

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