ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis

European Radiology
Leticia MaffazzioliRichard R Gurski

Abstract

Diffusion-weighted magnetic resonance imaging (DWI) is part of clinical practice. The aim of this study was to evaluate the role of apparent diffusion coefficient (ADC) as a predictor of pathologic response to neoadjuvant therapy (nCRT) in patients with esophageal cancer (EC). The MEDLINE, Embase, and Google Scholar databases were systematically searched for studies using ADC to evaluate response to neoadjuvant therapy in patients with EC. Methodological quality of the studies was evaluated with the QUADAS tool. Data from eligible studies were extracted and evaluated by two independent reviewers. Meta-analyses were performed comparing mean ADC values between responders and non-responders to nCRT in three different scenarios: baseline (BL) absolute values; percent change between intermediate (IM) values and BL; and percent change between final follow-up (FU) value and baseline BL. Seven studies (n = 158 patients) were included. Responders exhibited a statistically significant percent increase in ADC during nCRT (mean difference [MD] 21.06%, 95%CI = 13.04-29.09; I2 = 49%; p = 0.12). A similar increase was identified in the complete pathologic response (pCR) versus non-complete pathologic response (npCR) subgroup (MD = 25.68%, 95%...Continue Reading

References

Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R Padhani
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yael MardorThomas Tichler
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C BergerMelvyn Goldberg
Jun 24, 2006·The British Journal of Radiology·D-M Koh, A R Padhani
Aug 19, 2006·Magnetic Resonance Imaging·Martin D PicklesLindsay W Turnbull
Feb 4, 2009·Neoplasia : an International Journal for Oncology Research·Anwar R PadhaniPeter L Choyke
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Harriet C Thoeny, Brian D Ross
Apr 26, 2011·International Journal of Radiation Oncology, Biology, Physics·Vincent VandecaveyeRobert Hermans
Aug 31, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Uday B PatelGina Brown
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Feb 14, 2013·European Radiology·Peter S N van RossumJelle P Ruurda
Oct 12, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Georges DeckerWinfried A Willinek
Dec 30, 2014·The New England Journal of Medicine·Anil K Rustgi, Hashem B El-Serag
May 24, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter S N van RossumIrene M Lips
Oct 17, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Q-W LiH Liu
Apr 25, 2018·International Journal of Radiation Oncology, Biology, Physics·Penny FangSteven H Lin

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