Add-back therapy with GnRH analogues for uterine fibroids

The Cochrane Database of Systematic Reviews
Rafael M MoroniLuiz Gustavo Brito

Abstract

Uterine fibroids (also known as leiomyomas) are the most common benign pelvic tumours among women. They may be asymptomatic, or may be associated with pelvic symptoms such as bleeding and pain. Medical treatment of this condition is limited and gonadotropin-releasing hormone (GnRH) analogues are the most effective agents. Long-term treatment with such agents, however, is restricted due to their adverse effects. The addition of other medications during treatment with GnRH analogues, a strategy known as add-back therapy, may limit these side effects. There is concern, however, that add-back therapy may also limit the efficacy of the GnRH analogues and that it may not be able to completely prevent their adverse effects. To assess the short-term (within 12 months) effectiveness and safety of add-back therapy for women using GnRH analogues for uterine fibroids associated with excessive uterine bleeding, pelvic pain, or urinary symptoms. We searched electronic databases including the Cochrane Menstrual Disorders and Subfertility Group (MDSG) Specialised Register, CENTRAL, MEDLINE, PubMed, EMBASE, LILACS, CINAHL, PsycINFO; and electronic registries of ongoing trials including ClinicalTrials.gov, Current Controlled Trials, World Health...Continue Reading

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Citations

Jul 19, 2017·Journal of Gynecology Obstetrics and Human Reproduction·Y Levy-ZaubermanH Fernandez
Dec 21, 2017·F1000Research·Alistair R W Williams
Jul 31, 2018·Expert Opinion on Drug Metabolism & Toxicology·Mohamed Ali, Ayman Al-Hendy
Nov 16, 2017·The Cochrane Database of Systematic Reviews·Anne LethabyBeverley Vollenhoven
Jan 10, 2018·BioMed Research International·H H ChillA Shushan
Mar 9, 2021·Expert Review of Clinical Pharmacology·Mohamed AliAyman Al Hendy

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