"Add-on" effect of phytosterols-enriched fermented milk on lipids and markers of cholesterol metabolism in statin-treated elderly patients

Steroids
Isabel AndradeFernando Ramos

Abstract

The effect of plant sterol (PS) enriched matrices on lipid profile has been evaluated in statin-treated individuals, with LDL-C concentrations between 3.35mmol/L and 4.90mmol/L, but studies in the elderly are scarce. In this study the additional effect of a low-fat PS-enriched fermented milk (PS-FM) on cholesterol metabolism markers and serum lipids was evaluated in the elderly on stable statin therapy with baseline LDL-C<3.35mmol/L. Thirty-five individuals (88.6% women; 81±8years old; BMI 29.9±6.0kg/m(2)), living in elderly nursing care facilities were placed on a daily intake of 2g PS-FM for 6weeks, in addition to their statin monotherapy. A fasting blood sample was collected at baseline (t0), after 2 consecutive periods of 3weeks intake (t1 and t2), and after 6weeks of washout (t3), for the analysis of serum lipid profile and cholesterol synthesis (lathosterol, desmosterol) and absorption (sitosterol, campesterol and cholestanol) markers. PS-FM consumption led to a LDL-C reduction of 0.15mmol/L (t1) and 0.27mmol/L (t2) from baseline (P<0.05). Serum campesterol and sitosterol (P<0.001) increased (t0-t1; t0-t2), reflecting PS intake and contributing to the inhibition of cholesterol intestinal absorption, leading to a decrease ...Continue Reading

References

Feb 1, 1989·Metabolism: Clinical and Experimental·T A MiettinenY A Kesäniemi
Oct 20, 2000·European Journal of Human Genetics : EJHG·H GudmundssonK Stefánsson
Jun 1, 1960·Archives of Biochemistry and Biophysics·N J JACOBS, P J VANDEMARK
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anna KetomäkiTatu A Miettinen
May 5, 2010·Journal of the American College of Nutrition·Jennifer M ScholleCraig I Coleman
May 18, 2010·Scandinavian Journal of Primary Health Care·Päivi TuikkalaHannes Enlund
Aug 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Kozo OkadaSatoshi Umemura
Nov 18, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David SaraivaFernando Ramos
Feb 16, 2012·European Heart Journal·Bernd GenserWinfried März
Oct 11, 2012·BMC Systems Biology·Mark T Mc AuleyThomas B L Kirkwood
Nov 28, 2012·Journal of Lipid Research·Lily JakuljErik S G Stroes

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