Add-on probiotics in patients with persistent allergic rhinitis: A randomized crossover clinical trial

The Laryngoscope
Mir Mohammad JalaliHooman Ganjeh Khosravi

Abstract

Current medications for allergic rhinitis (AR) may have undesirable side effects that could affect quality of life (QoL). Probiotics could be an alternative in these patients. The aim of this study was to assess the impact of add-on probiotics on symptoms and QoL of patients. In this randomized crossover clinical trial, patients with persistent AR were included. Each subject received budesonide with probiotic supplements (BP) or budesonide with placebo for 8 weeks (B), then vice versa for a further 8 weeks. There was an 8-week washout. The primary outcome was the change of the Short Form 36-Item Health Survey (SF-36) score. The secondary outcomes were assessed by the Sinonasal Outcome Test-22 (SNOT-22) and the Control of Allergic Rhinitis and Asthma Test (CARAT) questionnaires. A total of 152 subjects (30.1 ± 7.6 years) completed the study. The SF-36 score in both groups showed improvement compared with baseline values. Treatment BP was more effective than that of B. The Cohen's d and the number needed to treat for Physical Component Scales of SF-36 were 0.40 and 10.77, respectively. These values for Mental Component Scales were 0.33 and 12.61, respectively. Also, treatment BP showed more reduction in the score of SNOT-22 and C...Continue Reading

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Citations

Jan 17, 2021·American Journal of Otolaryngology·Alexandra T Bourdillon, Heather A Edwards
May 11, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sophia LintonAnne K Ellis
Jul 3, 2021·Nutrients·Leontien Depoorter, Yvan Vandenplas
Aug 1, 2021·Clinical Nutrition ESPEN·Kontham Kulangara VarshaKesavan Madhavan Nampoothiri

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