Add-on therapy with dapagliflozin under full closed loop control improves time in range in adolescents and young adults with type 1 diabetes: The DAPADream study.

Diabetes, Obesity & Metabolism
Torben BiesterThomas Danne

Abstract

To investigate the effect of the sodium-glucose co-transporter-2 inhibitor dapagliflozin on glucose levels overnight and during the following day after two unannounced meals under full closed loop (FCL) conditions. For this single-centre, double-blind, randomized, placebo-controlled, cross-over trial, non-obese persons with type 1 diabetes (T1D) were studied twice (10 mg dapagliflozin bid vs. placebo) for 24 hours with two unannounced mixed meal tests 6 hours apart under FCL conditions. Primary outcome was sensor glucose time in range (TIR; 3.9-10 mmol/L). For safety evaluation, ß-hydroxybutyrate (BHB), glucagon, insulin and gastric inhibitory polypeptide were measured. Fifteen adolescents (aged 15.4 ± 1.6 years, diabetes duration 10.0 ± 3.4 years, HbA1c 8.4% ± 0.9% [67.7 ± 10.1 mmol/mol]) and 15 young adults (aged 18.7 ± 0.8 years; diabetes duration 12.5 ± 3.6 years; HbA1c 8.3% ± 0.9% [68.5 ± 11.2 mmol/mol]) completed the trial. TIR was significantly higher in the intervention group compared with placebo (68% ± 6% vs. 50% ± 13%; P < .001); nocturnal glucose was significantly lower with dapagliflozin (6.2 ± 0.7 vs. 7.3 ± 1.7 mmol/L; P = .003) without an increase in time at less than 3.9 mmol/L (3.3% ± 6.0% vs 3.1% ± 5.2%; P = ....Continue Reading

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Citations

Jul 29, 2021·Journal of Diabetes Science and Technology·Shylaja SrinivasanEda Cengiz
Aug 18, 2021·Expert Opinion on Pharmacotherapy·Stavroula Veneti, Konstantinos Tziomalos
Sep 25, 2021·Journal of Diabetes Science and Technology·Melissa-Rosina PasquaAhmad Haidar
Sep 22, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Hood ThabitLalantha Leelarathna
Oct 19, 2021·Diabetes, Obesity & Metabolism·Torben BiesterKlemen Dovc

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