Added prognostic value of CT characteristics and IASLC/ATS/ERS histologic subtype in surgically resected lung adenocarcinomas

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Young Joo SuhDoo Hyun Chung

Abstract

Our study investigates the added value of computed tomography (CT) characteristics, histologic subtype classification of the International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS), and genetic mutation for predicting postoperative prognoses of patients who received curative surgical resections for lung adenocarcinoma. We retrospectively enrolled 988 patients who underwent curative resection for invasive lung adenocarcinoma between October 2007 and December 2013. Cox's proportional hazard model was used to explore the risk of recurrence-free survival, based on the combination of conventional prognostic factors, CT characteristics, IASLC/ATS/ERS histologic subtype, and epidermal growth factor receptor (EGFR) mutations. Incremental prognostic values of CT characteristics, histologic subtype, and EGFR mutations over conventional risk factors were measured by C-statistics. During median follow-up period of 44.7 months (25th to 75th percentile 24.6-59.7 months), postoperative recurrence occurred in 248 patients (25.1%). In univariate Cox proportion hazard model, female sex, tumor size and stage, CT characteristics, and predominant histologic subtype we...Continue Reading

Citations

Apr 2, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David Allan MooreJohn Le Quesne
May 2, 2020·European Radiology·Jooae ChoeJoon Beom Seo
Nov 11, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jung Hee HongSoon Ho Yoon
Oct 22, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Young Joo SuhYoung Tae Kim

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