Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease

Parkinson's Disease
Dagmar BerankovaIrena Rektorova

Abstract

Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitiv...Continue Reading

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Citations

Sep 14, 2015·Parkinsonism & Related Disorders·Nela ElfmarkováIrena Rektorová
May 31, 2016·Parkinsonism & Related Disorders·Irena RektorovaRadek Marecek
Mar 9, 2017·Journal of Neural Transmission·Zoe Joanna SyrimiIrena Rektorova
Dec 18, 2019·Dementia & Neuropsychologia·Yunier Broche-PérezFiliberto Toledano-Toledano
Oct 31, 2019·Parkinson's Disease·Ashani JeyadevanRyan S Anderton
Jan 16, 2021·The European Journal of Neuroscience·Nahid ZokaeiAnna Christina Nobre

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Methods Mentioned

BETA
MDS

Software Mentioned

MATLAB
R
MAST
ACE
SPSS

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