Addiction as an Attachment Disorder: White Matter Impairment Is Linked to Increased Negative Affective States in Poly-Drug Use

Frontiers in Human Neuroscience
Human-Friedrich UnterrainerA Fink

Abstract

Substance use disorders (SUD) have been shown to be linked to various neuronal and behavioral impairments. In this study, we investigate whether there is a connection between the integrity of white matter (WM) and attachment styles as well as different affective states including spirituality in a group of patients diagnosed for poly-drug use disorder (PUD) in comparison to non-clinical controls. A total sample of 59 right-handed men, comprising the groups of patients with PUD (n = 19), recreational drug-using individuals (RUC; n = 20) as well as non-drug using controls were recruited (NUC; n = 20). For the behavioral assessment, we applied the Adult Attachment-Scale, the Affective Neuroscience Personality-Scale (short version) and the Multidimensional Inventory for Religious/Spiritual Well-Being. Diffusion Tensor Imaging was used to investigate differences in WM neural connectivity. Analyses revealed decreased Fractional Anisotropy and decreased Mean Diffusivity in PUD patients as compared to RUC and NUC. No differences were found between RUC and NUC. Additional ROI analyses suggested that WM impairment in the superior longitudinal fasciculus (SLF) and the superior corona radiata (SCR) was linked to more insecure attachment as ...Continue Reading

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Citations

Dec 7, 2017·Der Nervenarzt·H F UnterrainerH P Kapfhammer
Sep 12, 2019·Frontiers in Psychiatry·Michaela Hiebler-Ragger, Human-Friedrich Unterrainer
Sep 24, 2019·Frontiers in Psychiatry·Jürgen FuchshuberHuman Friedrich Unterrainer
Oct 22, 2019·Frontiers in Psychiatry·Sonja JungChristian Montag
Jun 26, 2020·Frontiers in Psychiatry·Jürgen Fuchshuber, Human Friedrich Unterrainer
Jul 2, 2019·Frontiers in Psychiatry·David Ramirez-CastilloIgnacio Morón
Sep 24, 2019·Frontiers in Psychiatry·Jürgen FuchshuberHuman Friedrich Unterrainer
Apr 5, 2018·Frontiers in Psychology·Michaela Hiebler-RaggerHuman F Unterrainer
Oct 18, 2019·Frontiers in Psychiatry·Christiane EichenbergAthina Schroiff

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Software Mentioned

FMRIB Software Library
FMRIB
TOPUP
SEEKING
SADNESS
Diffusion Toolbox of FSL ( FDT
FMRIB Library
Brain Extraction Tool
eddy
FNIRT

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