Adding concurrent low dose continuous infusion of cisplatin to radiotherapy in locally advanced cervical carcinoma: a prospective randomized pilot study

The British Journal of Radiology
M GaripağaoğluG Tulunay

Abstract

The tolerability and efficacy of the continuous infusion of cisplatin during radiotherapy was studied by tumour response, survival and pelvic control, in carcinoma of the cervix. 44 patients with stage IIB-IIIB cervical carcinoma were prospectively randomized into two groups: radiation alone (control group) versus radiation plus cisplatin (study group). While there was no significant difference in diarrhoea and urinary complication scores, emesis and appetite changes were significantly greater in the study group. Tumour responses were no different at the end of the treatment and 3 months after completion of treatment. After 40 months median follow-up, 40/44 patients were assessed (one had a second primary tumour and three were lost to follow-up). Persistent disease was found in 3 patients: one in the study arm and two in the control arm. Recurrence was seen in 10 patients in the first 2 years. 5-year pelvic control rates were; 69.4% and 63.9% (p=0.7), survival rates were 52.0% and 48.9% (p=0.7) and disease-free survival rates were 67.5% and 58.7% (p=0.3) for the control and the study groups, respectively. Although the continuous infusion of cisplatin during radiotherapy was well tolerated, this additional treatment did not appe...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A FylesJ Simm
Jan 1, 1992·Frontiers of Radiation Therapy and Oncology·I F Tannock
Jun 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L SouhamiT R Silveira
Sep 1, 1990·Gynecologic Oncology·G ThomasB Black
Feb 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A ReeceC L Olweny
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M H MaorP Gardner
Oct 15, 1987·Cancer·T ThigpenR McGehee
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A PerezB J Walz
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·L W BradyJ M Bedwinek
Aug 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P BonomiF J Major
Jan 1, 1973·The British Journal of Radiology·G H Fletcher
Jun 1, 1995·American Journal of Public Health·D T JanerichA P Polednak
Feb 15, 1995·International Journal of Radiation Oncology, Biology, Physics·D ArthurM Ali
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·R A Potish, L B Twiggs
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F B StehmanW T Creasman
Feb 15, 1993·International Journal of Radiation Oncology, Biology, Physics·R M LancianoG E Hanks
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F TierneyM K Parmar
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·P PisaniJ Ferlay
Feb 15, 2000·Seminars in Radiation Oncology·R Lanciano
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·M ChunE Lee
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·S NagD Petereit
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyP Eifel
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P G Rose
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter G Rose, Brian N Bundy
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R PearceyD Tu
Apr 2, 2002·Gynecologic Oncology·Charles J DuntonKelly Underhill

❮ Previous
Next ❯

Citations

Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration
Jul 14, 2010·Journal of Cancer Research and Therapeutics·R R NegiMadhup Rastogi
Jun 24, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·J F TierneyP Symonds
Jan 22, 2010·The Cochrane Database of Systematic Reviews·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC)
Aug 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rajiv SamantMichael Fung-Kee-Fung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
M M HreshchyshynJohn A Blessing
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R P SymondsT Sarkar
© 2022 Meta ULC. All rights reserved