Adding ezetimibe to statin therapy: latest evidence and clinical implications

Drugs in Context
Marija Vavlukis, Ana Vavlukis

Abstract

Statins are the hypolipemic treatment of choice for hyperlipidemia with confirmed atherosclerotic cardiovascular disease (ASCVD) protective effect, proven even in normolipemic patients. But in rare situations, even with a high-dose treatment regimen, or maximally tolerated statin dose treatment, treatment targets of low-density lipoprotein cholesterol (LDL-C), according to the risk profile of the patient, cannot be achieved. Combination therapy with ezetimibe is an effective treatment choice, as it is one of the few hypolipemic drugs with proven ASCVD protective effect. In this review, we address the question of therapeutic efficacy and safety of ezetimibe in combination therapy with statins, as expressed through its hypolipemic and vasoprotective effects and its potential side effects. We conducted a literature review of English articles through PubMed, PubMed Central, and Cochrane for randomized clinical trials, retrospective analyses, meta-analyses, and review articles by using key words: ezetimibe, statins, combination therapy, adverse effects. We analyzed data on ezetimibe-statin combination therapy in terms of hypolipemic efficacy, ASCVD risk reduction, and adverse effects. Statins have been proven to be very effective in...Continue Reading

Citations

Apr 22, 2019·The Medical Journal of Australia·Leon A Simons
Jun 30, 2019·Journal of Pharmacy Practice·Mary Caitlin Baggett, Diane Nykamp
Nov 15, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Fadia Tohme ShayaMiraj Y Patel
Jan 6, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dimittri Delevry, Eric K Gupta
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Mikaiel HajializadeAli Yeganeh
Aug 29, 2021·Pharmaceutics·Nolwenn TessierCatherine Martel

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