PMID: 8948303Nov 1, 1996Paper

Adding low-dose cyclosporin A to parenteral gold therapy in rheumatoid arthritis: a double-blind placebo-controlled study

British Journal of Rheumatology
G Bendix, A Bjelle

Abstract

A double-blind, randomized comparison between parenteral gold therapy (PGT) and cyclosporin A (CyA) vs PGT and placebo during 6 months was performed in 40 RA patients experiencing a decreasing effect of ongoing PGT. Patients' overall assessment of health was the only efficacy variable significantly better in the CyA- and PGT-treated vs the placebo- and PGT-treated group. Higher blood pressure and more signs of renal impairment were found during the 6 months treatment in the former compared with the latter group. Six months after the end of the combination therapy, a higher potassium value in the CyA-treated group was the only difference. In conclusion, no effects additional to those expected with single-drug therapy or additional risks of side-effects of either drug were found when combining low-dose CyA with ongoing PGT in RA patients with long disease duration.

Citations

Jun 1, 1994·Journal of Clinical Pharmacy and Therapeutics·N J Gittoes
Dec 21, 2000·Current Rheumatology Reports· St Clair EW
Nov 2, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Alireza MohammadiGholamhossein R Omrani
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·P L van RielD E Furst
Aug 16, 2016·Clinical Reviews in Allergy & Immunology·Cecilia Beatrice ChighizolaPier Luigi Meroni
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Nadège RobertJames M Wright
Sep 7, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·T Garrood, D L Scott
Apr 7, 2007·Current Opinion in Rheumatology·Kanako Kitahara, Shinichi Kawai
Oct 18, 2011·Journal of Hypertension·Gian P RossiAchille C Pessina

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