Adding mindfulness-based cognitive therapy to maintenance antidepressant medication for prevention of relapse/recurrence in major depressive disorder: Randomised controlled trial

Journal of Affective Disorders
Marloes J HuijbersAnne E M Speckens

Abstract

Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied. Our aim was to investigate whether the addition of MBCT to mADM is a more effective prevention strategy than mADM alone. This study is one of two multicenter randomised trials comparing the combination of MBCT and mADM to either intervention on its own. In the current trial, recurrently depressed patients in remission who had been using mADM for 6 months or longer (n=68), were randomly allocated to either MBCT+mADM (n=33) or mADM alone (n=35). Primary outcome was depressive relapse/recurrence within 15 months. Key secondary outcomes were time to relapse/recurrence and depression severity. Analyses were based on intention-to-treat. There were no significant differences between the groups on any of the outcome measures. The current study included patients who had recovered from depression with mADM and who preferred the certainty of continuing medication to the possibility of participating in MBCT. Lower expectations of mindfulness in the current trial, compared with the parallel trial, may have caused selection bias. In addition, recruitme...Continue Reading

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Citations

Feb 20, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Marloes J HuijbersAnne E M Speckens
Jul 26, 2017·Contemporary Clinical Trials·Daniel J Safer
May 21, 2019·The Cochrane Database of Systematic Reviews·Katja MachmutowSarah Liebherz
Nov 19, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Josefien Johanna Froukje BreedveltClaudi Louisa Hermina Bockting

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