Adding plasmapheresis to corticosteroids and alkylating agents: does it benefit patients with focal segmental glomerulosclerosis?

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A H Mitwalli

Abstract

Eleven adult patients with biopsy-proven primary FSGS and nephrotic syndrome resistant to steroids and cytotoxic drugs were treated with plasmapheresis in addition to oral prednisolone and intravenous cyclophosphamide. On the average each patient had undergone 17 sessions over a period of 15-25 weeks (mean 21.90+/-2.71 weeks). One month after the last plasmapheresis session, 72.7% (n=8) of the patients were in clinical remission of nephrotic syndrome in association with the stabilization of renal function. In contrast, patients who did not respond 27.3% (n=3) had a gradual decline in renal function. After a mean follow-up of 27.45+/-6.31 months, six patients who responded (54.5%) remained in sustained complete or partial remission of proteinuria with stable renal function. The mean proteinuria at the latest examination was 0.9+/-0.01 g per day in these patients. It is concluded that a combination of plasmapheresis, corticosteroids, and cyclophosphamide may obtain sustained improvement of proteinuria and stabilization of plasma creatinine in about half of the patients who proved to be refractory to therapy.

Citations

Nov 17, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Debbie S GipsonMarva Moxey-Mims
Sep 5, 2002·Journal of Clinical Anesthesia·Bhiken NaikVikas R Dharnidharka
Nov 13, 2002·Kidney International·Stephen M Korbet
Jul 27, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·T Bosch, T Wendler
May 2, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Eriko IshiiYasushi Asano
Apr 22, 2003·Seminars in Nephrology·Claudio Ponticelli, Patrizia Passerini
May 18, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vedat Schwenger, Christian Morath
Mar 18, 2003·Current Opinion in Pediatrics·Corinne Benchimol
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·P Passerini, C Ponticelli
Mar 21, 2012·Seminars in Dialysis·Amber P Sanchez, David M Ward
Dec 3, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nilay Sengul SamanciSavas Ozturk
Mar 1, 2013·Expert Review of Clinical Immunology·Claudio Ponticelli, Giorgio Graziani
Feb 7, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J Chemli, A Harbi
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V BroumandA Fogo
Sep 2, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Sanz-Guajardo
May 15, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Lily OliveiraBrendan B McCormick
Feb 6, 2015·Clinical and Experimental Nephrology·Kenji IshikuraUNKNOWN Japanese Society for Pediatric Nephrology
Nov 7, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Maria Teresa Jaldo RodríguezMaria Pilar Pérez Del Barrio
May 5, 2017·Journal of Nephrology·Mirco BelingheriPiergiorgio Messa

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