Adding rituximab to CODOX-M/IVAC chemotherapy in the treatment of HIV-associated Burkitt lymphoma is safe when used with concurrent combination antiretroviral therapy

AIDS
Ferras AlwanKate Cwynarski

Abstract

CODOX-M/IVAC (cyclophosphamide, vincristine, doxorubicin-methatrexate/ifusamide, etoposide, cytarabine) chemotherapy is commonly used to treat Burkitt lymphoma and in the HIV-negative population. Rituximab is often added with suggested survival benefits. Concerns over increased toxicity in an already immunocompromized population have prevented its routine addition in people living with HIV (PLWH). This study evaluated the effect on treatment-related toxicity and efficacy of adding rituximab to CODOX-M/IVAC chemotherapy in PLWH. Retrospective review of 91 PLWH (74 men) with Burkitt lymphoma treated in five London centers between 2003 and 2013. All patients received combination antiretroviral therapy. Forty-nine patients received CODOX-M/IVAC and 42 rituximab (R)-CODOX-M/R-IVAC. The addition of rituximab did not confer any significant increase in grade 3/4 toxicities including infections, mucositis, diarrhea, renal impairment, and tumor lysis syndrome. There was no significant difference in toxic deaths between groups (P = 0.14). The 2-year overall survival (OS) was greater for patients receiving rituximab {2-year OS 72% [95% confidence interval (CI) 0.22-0.92, hazard ratio 0.46] vs. 55% [95% CI 1.1-4.5, hazard ratio 2.2]; log-ra...Continue Reading

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Citations

Dec 24, 2015·Cancer Chemotherapy and Pharmacology·Alessia Dalla PriaMark Bower
May 20, 2017·Clinical Journal of Gastroenterology·Prabin SharmaAmir Masoud
Dec 20, 2017·International Reviews of Immunology·Omid RezahosseiniNima Rezaei
Feb 14, 2017·Biomarker Research·Tasleem Katchi, Delong Liu
Jan 28, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam J OlszewskiAndrew M Evens
Feb 18, 2021·International Journal of Hematology·Zhenyan WangHongzhou Lu
Jul 12, 2021·Bulletin du cancer·Illias Tazi, Fatima Zahra Lahlimi

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