Addition of [18 F]Fluorodeoxyglucose Positron Emission Tomography With Computed Tomography to Cross-Sectional Imaging Improves Staging and Alters Management in Hepatocellular Carcinoma.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Binu V JohnJames L Tatum

Abstract

In this work, we characterize the value of positron emission tomography (PET) with computed tomography (CT) in combination with cross-sectional imaging for staging and prognostication of hepatocellular carcinoma (HCC) patients. In this retrospective cohort study, HCC patients underwent PET-CT after initial staging with contrast-enhanced CT or magnetic resonance imaging (MRI). The benefit of PET-CT was measured by the identification of new HCC lesions, and potential harm was quantified by the number of false positives and subsequent diagnostic evaluation. We used multivariate Cox regression analysis to evaluate the association between the highest grade on PET-CT with the risk of extrahepatic metastasis, progression-free, and overall survival. Among 148 patients, PET-CT detected additional extrahepatic metastasis in 11.9% of treatment-naïve and 13.8% of treatment-experienced patients. PET-CT changed the Barcelona Clinic Liver Cancer (BCLC) staging in 5.9% of treatment-naïve and 18.8% of treatment-experienced patients compared with CT/MRI alone, changing HCC management in 9.9% and 21.3% of patients, respectively. Of the patients, 5% (n = 8) experienced severe physical harm requiring additional procedures to evaluate extrahepatic f...Continue Reading

References

Mar 26, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tara J SelmanKhalid Khan
Feb 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A KornbergU Settmacher
Oct 31, 2009·World Journal of Hepatology·Long SunHua Wu
Oct 18, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Guozeng XuZhiyi He
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Omair AtiqAmit G Singal
Oct 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sae Jung NaMijin Yun
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lewis R RobertsKhaled Mohammed
Nov 24, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Seung Hyup HyunMijin Yun
Dec 22, 2017·Annals of Hepato-biliary-pancreatic Surgery·Kyung Jin ChoA Ri Chong
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach
Nov 8, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Chetana LimDaniel Azoulay

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Citations

Apr 15, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Neehar Parikh, Anjana Pillai
Mar 17, 2021·Nuclear Medicine and Biology·Ai-Mei LiMing Shi
Jun 7, 2021·Abdominal Radiology·Sandeep AroraAmir A Borhani

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