PMID: 9535451Apr 16, 1998Paper

Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury

The Journal of Thoracic and Cardiovascular Surgery
M L BarrV A Starnes

Abstract

Research in lung transplant preservation has generally focused on free radicals and enzyme release from neutrophils, parenchymal cells, macrophages, and endothelium. The lung has a large resident population of mast cells that, when activated, release potent inflammatory mediators. We hypothesized that adding an inhibitor of mast cell degranulation, lodoxamide tromethamine (10 micromol/L), to Euro-Collins and University of Wisconsin preservation solutions, would decrease lung preservation injury. Rat lungs were isolated, flushed with the respective solution, and stored at 4 degrees C for 6 or 12 hours. The lungs were reperfused with fresh blood and ventilated with 100% oxygen. Alveolar-arterial oxygen difference, oxygen tension, capillary filtration coefficient, and compliance were determined. After 6 hours of ischemic storage: lodoxamide tromethamine-enhanced Euro-Collins solution decreased alveolar-arterial oxygen difference from 539 to 457 (p = 0.004), increased oxygen tension from 119 to 205 mm Hg (p = 0.006), and decreased capillary filtration coefficient from 3.9 to 2.0 (p < 0.001); lodoxamide tromethamine-enhanced University of Wisconsin solution decreased alveolar-arterial oxygen difference from 546 to 317 (p < 0.001), i...Continue Reading

References

Feb 1, 1992·The Annals of Thoracic Surgery·R AebaB P Griffith
Aug 1, 1989·Journal of Cardiovascular Pharmacology·C F VealJ D Fulmer
Jan 17, 1985·The New England Journal of Medicine·J M McCord
May 1, 1988·The Journal of Surgical Research·M J LynchM L Morganroth
Nov 1, 1981·Agents and Actions·G J White
May 1, 1982·Journal of Cardiovascular Pharmacology·S R JollyB R Lucchesi

❮ Previous
Next ❯

Citations

Aug 5, 2000·The Journal of Pathology·B LazarusK R Knight
Jul 31, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·N R. Harris, R E. Rumbaut
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cathal O'KeeffeP Aiden McCormick
Jul 8, 2009·Current Opinion in Organ Transplantation·Victor C de VriesRandolph J Noelle
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Apr 29, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jui-Chih ChangShu S Lin
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V C de VriesR J Noelle
Jan 8, 2004·Acta Physiologica Hungarica·M Boros
Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C MukundanD S Friend
Nov 7, 2000·British Journal of Anaesthesia·A L Mundy, K L Dorrington
Dec 5, 2018·Journal of Immunology Research·Esmaeil MortazGert Folkerts
Apr 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·A MessinaA G Stewart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
Q LüZ Q Sun
Clinical Transplantation
S BalupuriD Talbot
Scandinavian Journal of Clinical and Laboratory Investigation
S SkjeldalO Reikarås
© 2022 Meta ULC. All rights reserved