PMID: 1132951May 1, 1975Paper

Addition of calcium or other cations and of oxygen to ionic and non-ionic contrast media. Effects on cardiac function during coronary arteriography

Investigative Radiology
B TrägårdhP R Lynch

Abstract

Metrizamide is a new non-ionic water soluble contrast agent. Isolated rabbit hearts were perfused with solutions of 1) metrizamide, 2) metrizamide with plasma equivalent amounts of cations, 3) oxygenated metrizamide, 4) oxygenated metrizamide with cations, 5) diatrizoate. Solutions of 1) metrizamide, 2) metrizamide with plasmaequivalent amounts of cations, 3) metrizamide with calcium ions, 4) metrizoate (ionic medium) with calcium ions, metrizoate with 5) low and 6) high sodium content and 7) diatrizoate were injected into the left coronary artery of dog hearts in vivo. Maximal change of myocardial contractile force was measured with a strain gauge arch. Changes in aortic blood pressures were also recorded. In both sets of experiments metrizamede affected these parameters less than the ionic contrast media. The addition of calcium ions to both ionic and non-ionic media reduced the adverse effects on the observed cardiac funcitons, while simultaneous addition of plasma equivalent amounts of four cations as metrizoate salts had no beneficial effects. Sodium ions had in high concentration deleterious effects on cardiac performance. Oxygen saturation of the contrast medium had no observable effect. The adverse effects on cardiac me...Continue Reading

Citations

Jan 1, 1982·Cardiovascular and Interventional Radiology·J R SerurS Paulin
Jan 1, 1981·Cardiovascular and Interventional Radiology·H G WolpersG Hellige
Sep 1, 1985·Journal of the American College of Cardiology·L D GillamA E Weyman
Oct 1, 1985·Journal of the American College of Cardiology·D L MorrisJ J Langberg
Jan 1, 1982·Acta Radiologica: Diagnosis·J WojciechowskiL Björk
Jan 1, 1983·Acta Radiologica: Diagnosis·K Selin, L Björk
Jan 1, 1983·Acta Radiologica: Diagnosis·B Trägårdh, P R Lynch
Aug 19, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·C IzciC Ceylan
Jan 1, 1984·Catheterization and Cardiovascular Diagnosis·D K MurdockP J Scanlon

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