Addition of droperidol to prophylactic ondansetron and dexamethasone in children at high risk for postoperative vomiting. A randomized, controlled, double-blind study

British Journal of Anaesthesia
N BourdaudVPOP2 group

Abstract

: The combination of dexamethasone (DEX), ondansetron (OND) and droperidol (DRO) is efficacious in preventing postoperative nausea and vomiting in adults, but has not been well assessed in children. : Children undergoing elective surgery under general anaesthesia and considered at high risk for postoperative vomiting (POV) were randomly assigned to receive a combination of DEX, OND and placebo (Group A) or a combination of DEX, OND and DRO (Group B). The primary outcome was the incidence of POV during the first 24 hours after surgery. We hypothesized that the addition of DRO to the standard antiemetic prophylaxis would provide a further 15% reduction in the residual risk for POV. The secondary outcome considered was any adverse event occurring during the study. : One hundred and fifty-three children, aged three to 16 years, were randomized to Group A and 162 to Group B. The overall incidence of POV did not differ significantly between the two groups, with 16 patients in Group A (10.5%) and 18 in Group B (11.1%) presenting with one or more episodes of POV, P =0.86. Fewer patients presented with adverse events in Group A (2%) compared with Group B (8%), P =0.01. Drowsiness and headache were the principal adverse events reported. ...Continue Reading

References

Aug 1, 1980·British Journal of Anaesthesia·L J Dupre, P Stieglitz
Jul 1, 1997·European Journal of Anaesthesiology·A Klockgether-RadkeH Mühlendyck
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I HenziM R Tramèr
Jun 11, 2004·The New England Journal of Medicine·Christian C ApfelUNKNOWN IMPACT Investigators
Oct 16, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·B ValletUNKNOWN Socie´te ´ franc ¸aise d’anesthe´sie et de re´animation

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Citations

May 30, 2020·Anesthesia and Analgesia·Tong J GanBeverly K Philip
Aug 5, 2020·Paediatric Anaesthesia·Florence Julien-MarsollierSouhayl Dahmani
Jul 23, 2020·Revista latino-americana de enfermagem·Isadora PierottiLígia Fahl Fonseca
Oct 28, 2020·Paediatric Drugs·Anthony L Kovac

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