PMID: 2494960Apr 1, 1989Paper

Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance

Annals of Surgery
F HammarqvistE Vinnars

Abstract

Twenty-two patients undergoing elective abdominal surgery were given total parenteral nutrition (TPN) after the operation. The TPN contained either a conventional amino acid solution supplemented with glutamine or a conventional amino acid solution without supplementation. To study amino acid and protein metabolism, muscle biopsy specimens were taken before surgery and on the third postoperative day. The postoperative decrease in the intracellular concentration of free glutamine was less pronounced in the glutamine group (21.8 +/- 5.5%) than in the control group (38.7 +/- 5.1%; p less than 0.05). The protein synthesis was reflected in the concentration and size distribution of ribosomes. No significant changes in these parameters were seen in the glutamine group after the operation. In the control group, the total concentration of ribosomes fell by 27.2 +/- 8.5% (p less than 0.05), and the relative proportion of polyribosomes fell by 10.6 +/- 2.9% (p less than 0.01). Although there were significant changes in the control group, no significant differences in the changes of these parameters between the two groups were detected. The cumulative nitrogen loss was significantly less in the glutamine group as compared to the control g...Continue Reading

References

May 1, 1979·Surgery·L H Aulick, D W Wilmore
Dec 1, 1978·Annals of Surgery·J AskanaziJ Bergström
Aug 1, 1986·Infusionstherapie Und Klinische Ernährung·J WernermanE Vinnars
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
Jan 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
May 1, 1985·Metabolism: Clinical and Experimental·W W SoubaD W Wilmore
Jul 1, 1985·Metabolism: Clinical and Experimental·J WernermanE Vinnars
Jan 1, 1971·The Journal of Clinical Investigation·J N CunninghamD W Seldin
Mar 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·E VinnarsB Schildt
Mar 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·G H ClowesC J Cha
Mar 1, 1960·Journal of Clinical Pathology·J K FAWCETT, J E SCOTT

❮ Previous
Next ❯

Citations

Feb 1, 1993·Amino Acids·A L Schaefer, S L Scott
Mar 1, 1993·World Journal of Surgery·J H Shaw, J B Koea
Mar 1, 1993·World Journal of Surgery·T Christensen, H Kehlet
Feb 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M VaubourdolleO G Ekindjian
Jun 1, 1992·Irish Journal of Medical Science·D J Hehir, T F Gorey
Jul 29, 2005·Amino Acids·A BergJ Wernerman
Dec 1, 1989·American Journal of Surgery·C P Page
Jan 1, 1995·Advances in Enzyme Regulation·J T BrosnanS A Squires
Mar 24, 1990·Lancet·J WernermanE Vinnars
May 29, 1993·Lancet·R R van der HulstP B Soeters
Aug 4, 1995·Journal of Chromatography. B, Biomedical Applications·J L LuoJ Wernerman
Jul 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B MoskovitzB Rosenberg
Aug 9, 2005·The International Journal of Biochemistry & Cell Biology·Gianni BioloBeniamino Ciocchi
Oct 21, 2004·Best Practice & Research. Clinical Gastroenterology·Jutta KellerPeter Layer
Jun 1, 1997·Disease-a-month : DM·B A Mizock, S Troglia
Apr 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·O E RooyackersA J Wagenmakers
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
Jun 1, 1996·Nutrition·R D Griffiths
Sep 18, 1997·Nutrition·T R ZieglerD P Griffith
Jul 31, 1998·Nutrition·D W Wilmore, J K Shabert
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·J WernermanP Essén
Dec 17, 2002·Current Opinion in Pharmacology·Julia S Hadley, Charles J Hinds
Sep 5, 1991·The New England Journal of Medicine·D W Wilmore
Jan 1, 1993·Nutrition Research Reviews·G K Grimble
Dec 1, 2004·Nutrition Research Reviews·Yvonne L J VissersNicolaas E P Deutz
Dec 25, 2003·The Proceedings of the Nutrition Society·Simon Eaton
Dec 1, 1993·Annals of Surgery·W W Souba
Jan 29, 2000·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·K Harding
Nov 9, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·E Mark Windle
Sep 22, 2007·Critical Care Medicine·Inga TjaderJan Wernerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.