Addition of Histology to the Paris Classification of Pediatric Crohn Disease Alters Classification of Disease Location

Journal of Pediatric Gastroenterology and Nutrition
Melissa A FernandesMelvin B Heyman

Abstract

The aim of the study was to investigate the value of microscopic findings in the classification of pediatric Crohn disease (CD) by determining whether classification of disease changes significantly with inclusion of histologic findings. Sixty patients were randomly selected from a cohort of patients studied at the Pediatric Inflammatory Bowel Disease Clinic at the University of California, San Francisco Benioff Children's Hospital. Two physicians independently reviewed the electronic health records of the included patients to determine the Paris classification for each patient by adhering to present guidelines and then by including microscopic findings. Macroscopic and combined disease location classifications were discordant in 34 (56.6%), with no statistically significant differences between groups. Interobserver agreement was higher in the combined classification (κ = 0.73, 95% confidence interval 0.65-0.82) as opposed to when classification was limited to macroscopic findings (κ = 0.53, 95% confidence interval 0.40-0.58). When evaluating the proximal upper gastrointestinal tract (Paris L4a), the interobserver agreement was better in macroscopic compared with the combined classification. Disease extent classifications diffe...Continue Reading

References

Oct 7, 2000·The American Journal of Surgical Pathology·R ValdezJ K Greenson
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·J M TobinM S Murphy
Jul 4, 2002·The American Journal of Gastroenterology·F SharifB Bourke
Nov 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Bisher A AbdullahJoseph F Fitzgerald
Mar 26, 2003·The American Journal of Gastroenterology·P S KundhalA M Griffiths
Mar 27, 2003·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Judy Mae PascasioStephen J Qualman
May 26, 2009·Current Gastroenterology Reports·Dan Turner, Anne M Griffiths
Jun 1, 2012·Current Opinion in Gastroenterology·Severine VermeirePaul Rutgeerts
Aug 13, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Silvia MazzuoliVincenzo Villanacci

❮ Previous
Next ❯

Citations

Apr 6, 2017·AJR. American Journal of Roentgenology·Ishrat MansuriJeanne Tung
Apr 7, 2016·Journal of Pediatric Gastroenterology and Nutrition·Dan TurnerAnne M Griffiths
Sep 19, 2017·Journal of Pediatric Gastroenterology and Nutrition·James J AshtonR Mark Beattie
Dec 3, 2015·Journal of Pediatric Gastroenterology and Nutrition·Dan Turner
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.